| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We investigated the effect of docosenoic acid and icosenoic acid, the abundant monounsaturated fatty acids in the saury oil, on the type-2 diabetic mellitus and atopic dermatitis. Supplementation with docosenoic acid and icosenoic acid had reduced Atopic dermatitis like skin lesions and the frequency of scratching episodes in a time-dependent manner on atopic NC/Nga mice. Furthermore, docosenoic acid and icosenoic acid had reduced weight and insulin sensitivity had improved on the type-2 diabetic KK-Ay mice. From these results, it appears that docosenoic acid and icosenoic acid can contribute to the prevention of a lifestyle-related disease and the allergic disease.
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