Development for novel food and feed using DNA Nanocapsules of Lactic acid bacteria as Oral Delivery Devices
Project/Area Number |
24580388
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Zootechnical science/Grassland science
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Research Institution | Shinshu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
YONEKURA Shinichi 信州大学, 学術研究院農学系, 助教 (40443113)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | DNAナノカプセル / DNanocap / 乳酸菌 / 経口 / オリゴ核酸 / ODN / iODN / ナノカプセル / マイクロカプセル / オリゴ核酸カプセル |
Outline of Final Research Achievements |
Chemosynthetic immuno-functional oligodeoxynucleotides (ODNs) are also useful as adjuvants for vaccines against infectious agents, cancer, allergies, and inflammatory disorders. For medical purposes, ODNs have been administered in a variety of ways, including via intraperitoneal (i.p.), intravenous (i.v.), and subcutaneous (s.c.) routes. There are few reports of oral (i.e., intragastric [i.g.]) administration of ODNs as a drug or food material. Here, we successfully developed a simple and low-cost oral oligodeoxynucleotide (ODN) delivery system, named DNA nanocapsules (DNanocaps).
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Inhibitory/suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice2015
Author(s)
Wang Y, Yamamoto Y, Shigemori S, Watanabe T, Oshiro K, Wang X, Wang P, Sato T, Yonekura S, Tanaka S, Kitazawa H, Shimosato T.
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Journal Title
Molecular Therapy
Volume: 23
Issue: 2
Pages: 297-309
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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