| Project/Area Number |
24580388
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YONEKURA Shinichi 信州大学, 学術研究院農学系, 助教 (40443113)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | DNAナノカプセル / DNanocap / 乳酸菌 / 経口 / オリゴ核酸 / ODN / iODN / ナノカプセル / マイクロカプセル / オリゴ核酸カプセル |
|---|
| Outline of Final Research Achievements |
Chemosynthetic immuno-functional oligodeoxynucleotides (ODNs) are also useful as adjuvants for vaccines against infectious agents, cancer, allergies, and inflammatory disorders. For medical purposes, ODNs have been administered in a variety of ways, including via intraperitoneal (i.p.), intravenous (i.v.), and subcutaneous (s.c.) routes. There are few reports of oral (i.e., intragastric [i.g.]) administration of ODNs as a drug or food material. Here, we successfully developed a simple and low-cost oral oligodeoxynucleotide (ODN) delivery system, named DNA nanocapsules (DNanocaps).
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