Research Project
Grant-in-Aid for Scientific Research (C)
Recently, we found the structurally related homeoproteins in both preimplantation mouse embryos and mouse ES cells. To identify roles of EGAM1 homeoproteins on embryogenesis, mouse ES cells stably expressing respective EGAM1 homeoproteins were generated. Upon exogenous expression in mouse ES cells, these homeoproteins can act as positive or negative regulators of differentiation, cell growth, and induction of gene expression involved in specific cellular functions of differentiated cell types. EGAM1 homeoproteins not only affect the generation of progenitor cells that arise during early embryogenesis, but also the progression of terminal differentiation, such as cardiomyogenesis, in mouse ES cells. Because EGAM1 homeoproteins are localized to the nuclei of mouse ES cells, it is probable that these proteins act as transcription factors. These results suggest that EGAM1 homeoproteins are crucial for progression of embryogenesis.
All 2016 2015 2014 2013 2012 Other
All Journal Article (22 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 22 results, Acknowledgement Compliant: 6 results, Open Access: 2 results) Presentation (44 results) (of which Invited: 1 results) Remarks (3 results)
Journal of Bioscience and Bioengineering
Volume: 印刷中 Issue: 5 Pages: 562-569
10.1016/j.jbiosc.2015.03.001
110010017123
Tohoku Journal of Animal Science and Technology (In Japanese)
Volume: 65 Pages: 14-21
Infection and Immunity
Volume: 83 Issue: 1 Pages: 138-145
10.1128/iai.02561-14
International Journal of the Society of Materials Engineering for Resources
Volume: 印刷中
130005106866
Biotechnology and Applied Biochemistry
Volume: 62 Issue: 2 Pages: 164-172
10.1002/bab.1251
Cytotechnology
Volume: (in press) Issue: 2 Pages: 191-197
10.1007/s10616-013-9686-8
Volume: 117 Issue: 5 Pages: 525-530
10.1016/j.jbiosc.2013.10.009
110009823125
Volume: 63 Pages: 38-43
Applied Biochemistry and Biotechnology
Volume: 172 Issue: 1 Pages: 206-215
10.1007/s12010-013-0544-0
Anal Biochem
Volume: 443 Issue: 1 Pages: 104-112
10.1016/j.ab.2013.08.014
Fungal Genetics and Biology
Volume: 58-59 Pages: 80-90
10.1016/j.fgb.2013.08.007
J Biosci Bioeng
Volume: S1389-1723 Issue: 2 Pages: 49-2
10.1016/j.jbiosc.2013.02.007
110009657192
Animal Science Journal
Volume: 84 Issue: 3 Pages: 275-280
10.1111/asj.12036
Volume: 63 Pages: 1-6
Applied Microbiology and Biotechnology
Volume: 97 Issue: 10 Pages: 4485-4498
10.1007/s00253-012-4565-3
Bioscience, Biotechnology, and Biochemistry
Volume: 77 Issue: 1 Pages: 173-177
10.1271/bbb.120698
10031164708
Volume: 62 Pages: 8-14
Tohoku Journal of Animal Science and Technology
Volume: 61 Pages: 35-40
Volume: 83 Issue: 3 Pages: 260-262
10.1111/j.1740-0929.2011.01000.x
130005457473
Reproduction
Volume: 143 Issue: 4 Pages: 477-489
10.1530/rep-11-0379
Volume: 114 Issue: 3 Pages: 342-346
10.1016/j.jbiosc.2012.04.012
110009517388
Biotechnology & Biotechnological Equipment
Volume: 26 Issue: 5 Pages: 3321-3323
10.5504/bbeq.2012.0079
http://www.akita-pu.ac.jp/bioresource/dbt/biochem/makoba/index.html