The role of HBEGF in bovine endometrial stem cell niche
| Project/Area Number |
24580419
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Iwate University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HASHIZUME Kazuyoshi 岩手大学, 農学部, 教授 (10355737)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ヘパリン結合性EGF様増殖因子 / HBEGF / 幹細胞 / 子宮 / 着床 / ウシ / ＨＢＥＧＦ |
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| Outline of Final Research Achievements |
In the present study, we investigated the role of heparin-binding EGF-like growth factor (HBEGF) on bovine endometrial stem cell niche. The present results demonstrated that EGFR and ERBB2 were highly expressed in caruncular endometrium, and HBEGF stimulated the proliferation and migration of endometrial stromal cells through the phosphorylation of ERK, but not in epithelial cells in vitro. These results suggest that endometrial stromal cells will be target cells for HBEGF, and indicating that endometrial stem cell may present in stroma layer in caruncle.
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Report
(4 results)
Research Products
(14 results)
