| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In the present study, we investigated the role of heparin-binding EGF-like growth factor (HBEGF) on bovine endometrial stem cell niche. The present results demonstrated that EGFR and ERBB2 were highly expressed in caruncular endometrium, and HBEGF stimulated the proliferation and migration of endometrial stromal cells through the phosphorylation of ERK, but not in epithelial cells in vitro. These results suggest that endometrial stromal cells will be target cells for HBEGF, and indicating that endometrial stem cell may present in stroma layer in caruncle.
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