Studies on mechanisms responsible for inhibin's action
| Project/Area Number |
24580421
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
ARAI Koji 東京農工大学, 農学部, 准教授 (70293016)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIYAMA Toshio 東京農工大学, 農学部, 教授 (60372455)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | インヒビン / 卵胞刺激ホルモン / アクチビン / フォリスタチン / 生理学 / 動物 / 生体分子 / 生理活性 / シグナル伝達 |
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| Outline of Final Research Achievements |
Inhibin, a member of the TGF-beta superfamily, regulates ovarian follicular development by specifically suppressing follicle-stimulating hormone secretion. It is suggested that inhibin suppresses FSH secretion by destabilizing FSH beta mRNA through its 3' untranslated region (3'UTR). Therefore, we have developed a mouse strain lacking the 3'UTR, and we are now analyzing characteristics of this strain. Furthermore, we developed a CHO cell line secreting rat recombinant inhibin to investigate mechanisms responsible for inhibin's action.
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Report
(4 results)
Research Products
(19 results)
