Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Outline of Final Research Achievements |
Rabies virus P gene encodes several P protein isoforms (P1-P3) in the same reading frame. While P1 protein functions as a co-factor of viral RNA polymerase, little is known about the functions of P2 and P3 proteins. In this study, the importance of these P protein isoforms in viral pathogenicity was examined. The results obtained from experiments with viral mutants overexpressing or lacking each isoform suggest that P1 protein is mainly related to the viral neuropathogenicity.
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