Analysis of gaseous messenger functions in the spinal dorsal horn.
| Project/Area Number |
24580426
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OHTA Toshio 鳥取大学, 農学部, 教授 (20176895)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | ガスメッセンジャー / 知覚神経 / 侵害受容器 / 疼痛 / 硫化水素 |
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| Outline of Final Research Achievements |
Hydorgen sulfide, a toxic volcanic gas, functions as a gaseous physiological and pathophysiological molecule similar to other ones, such as a carbon monoxide and a nitric monoxide. In this study, we demonstrated that the acidic condition enhanced the diffusion of hydrogen sulfide into the cytosol and the activation of TRPA1, a nociceptor. In addition, hydrogen sulfide enhanced and/or attenuated the spontaneous excitatory postsynaptic currents in lamina II neurons in spinal cord slices. These results suggest that the regulation of hydrogen sulfide production may be a target for a development of analgesic drugs.
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Report
(4 results)
Research Products
(13 results)
