| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
This study aimed to understand role of the novel transcription factors, PRX1 and PRX2. Using generated specific antibodies for PRX1 and PRX2, we demonstrated their presence in the pituitary stem/progenitor cells and in the extrapituitary cells invaded from surrounding mesenchyme and suggest that PRX1 and PRX2 are involved in pituitary organogenesis and vasculogenesis. In addition, we have found that TtT / GF cell derived from pituitary tumors expresses PRX1 and PRX2 and exhibits stemness with expressing several stem cell markers, showing a useful model cell to clarify their functions in molecular level.
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