The effect of hypertension on diabetic peripheral neuropathy in diabetic animal model.

Research Project

Project/Area Number	24580438
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	Setsunan University
Principal Investigator	OZAKI Kiyokazu 摂南大学, 薬学部, 准教授 (40268496)
Co-Investigator(Kenkyū-buntansha)	MATSUURA Tetsuro 摂南大学, 薬学部, 教授 (20268494) KODAMA Yasushi 広島国際大学, 薬学部, 講師 (40389119)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	糖尿病 / 末梢神経 / モデル動物 / 糖尿病末梢神経症 / 高血圧 / 動物モデル / 末梢神経症
Outline of Final Research Achievements	To investigate the effects of hypertension by Deoxycorticosterone(DOCA) and saline on diabetic peripheral neuropathy, we examined the peripheral nerves of alloxan-induced diabetic WBN/Kob rats. Hypertension and vascular lesions of peripheral nerves were induced in DOCA group, but there was no effect on nerve lesions. However, in saline group, vascular and nerve lesions were deteriolated. These findings indicate that saline-induced hypertension have effect on diabetic peripheral neuropathy.