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Basic study for assembling the picture of Borna Virus Infection

Research Project

Project/Area Number 24580442
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied veterinary science
Research InstitutionHokkaido University

Principal Investigator

Otsuka Yayoi  北海道大学, (連合)獣医学研究科, 客員研究員 (30396303)

Co-Investigator(Kenkyū-buntansha) SATO Kota  北海道大学, 大学院獣医学研究科, 准教授 (50283974)
Co-Investigator(Renkei-kenkyūsha) INABA Mutsumi  北海道大学, 大学院獣医学研究科, 教授 (00183179)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywordsボルナ病ウイルス / ボルナ病
Outline of Final Research Achievements

Borna disease virus (BDV) establishes persistent infection in the central nervous system and causes behavioral disturbances in several animal species including humans. BDV glycoprotein (BDVG) expression is extremely low in cells persistently infected with BDV and cells transfected with BDVG cDNA. Recently, avian bornavirus (ABV) was identified in parrots. In this study, we characterized ABV glycoprotein (ABVG) and reported that the expression of ABVG in transfected cells was remarkably higher than that of BDVG, despite similarities in their polypeptide backbone. We also showed that the amino acid sequence of the transmembrane domain affected plasma membrane expression levels of BDVG, and suggested the possible roles of host splicing factors in modulating the expression levels of BDVG.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2016 2013 2012 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results)

  • [Int'l Joint Research] スクリプス研究所(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] A new class of endoplasmic reticulum transmembrane proteins and its selective interaction with Sec24C2013

    • Author(s)
      Otsu, W., Kurooka, T., Otsuka, Y., Sato, K. and Inaba, M
    • Journal Title

      J. Biol. Chem

      Volume: (in press) Issue: 25 Pages: 18521-18532

    • DOI

      10.1074/jbc.m112.443325

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Modulatory roles of NHERF1 and NHERF2 in cell surface expression of the glutamate transporter GLAST2013

    • Author(s)
      Sato, K., Otsu, W., Otsuka, Y., Inaba, M.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 430(2) Issue: 2 Pages: 839-845

    • DOI

      10.1016/j.bbrc.2012.11.059

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] メトヘモグロビン血症を疑うポメラニアンの赤血球の生化学的解析2016

    • Author(s)
      篠春香、山﨑弥生(大塚)、佐藤龍也、小林沙織、内田直宏、佐藤れえ子、山﨑真大
    • Organizer
      第12回 日本獣医内科学アカデミー学術大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-02-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膜蛋白質小胞輸出の分子機構:新規シグナル配列ΦXΦXΦとSec24Cの選択的相互作用2013

    • Author(s)
      大津 航, 大塚 弥生, 宮園 耕介, 佐藤 耕太, 稲葉 睦
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Research-status Report
  • [Presentation] R664X 変異Anion Exchanger 1(AE1)の小胞体関連分解: AE1 と小胞体蛋白質との相互作用2013

    • Author(s)
      大津 航、大塚弥生、宮園耕介、佐藤 耕太, 稲葉 睦
    • Organizer
      日本膜学会第35 年会
    • Place of Presentation
      早稲田大学(東京都新宿区)
    • Related Report
      2013 Research-status Report
  • [Presentation] 新規COPII輸送モチーフφxφxφはSec23/24複合体との結合を介して膜内在性タンパク質の小胞体からの放出を促進する2012

    • Author(s)
      大津航、大塚弥生、佐藤耕太、稲葉睦
    • Organizer
      日本膜学会第34年会
    • Place of Presentation
      早稲田大学(新宿)
    • Related Report
      2012 Research-status Report
  • [Presentation] 新規COPII輸送モチーフφxφxφはSec23/24複合体との結合を介して膜内在性タンパク質の小胞体からの放出を促進する2012

    • Author(s)
      大津航、宮園耕介、大塚弥生、佐藤耕太、稲葉睦
    • Organizer
      第49回日本生化学会北海道支部例会
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 新規COPII輸送モチーフφxφxφはSec23/24複合体との結合を介して膜内在性タンパク質の小胞体からの放出を促進する2012

    • Author(s)
      大津航、宮園耕介、大塚弥生、佐藤耕太、稲葉睦
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      岩手大学(盛岡市)
    • Related Report
      2012 Research-status Report
  • [Presentation] R664X変異Anion Exchanger1(AE1)の小胞体関連分解:AE1と小胞体蛋白質との相互作用2012

    • Author(s)
      大津航、大塚弥生、宮園耕介、佐藤耕太、稲葉睦
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡(福岡市)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2022-02-03  

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