| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
A new Mycobacterium tuberculosis complex (MTC) species named Mycobacterium orygis, which seems to possess a wide host range, was isolated from lung TB regions in several animal species in Bangladesh and Nepal. Molecular characterizations of those isolates suggested the wide prevalence of M. orygis among wild animals in those areas. In Nepal, several M. tuberculosis isolates were obtained from captive elephants and some small structural changes by activated transposons were observed in their genomes. Analyses of those affected regions on the genomes together with comparative genomic analyses of M. orygis derived from different host species will provide us insights into the genetic regions associating with host range determination in MTC.
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