Epigenetics in the promoter region of prion protein gene
| Project/Area Number |
24580445
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Kobe University |
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Principal Investigator |
SAEKI Keiichi 神戸大学, (連合)農学研究科(研究院), 准教授 (10311630)
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| Co-Investigator(Kenkyū-buntansha) |
KAWANO Junichi 神戸大学, 大学院農学研究科, 教授 (40127361)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUO Eiko 神戸大学, 大学院農学研究科, 助教 (40620878)
TAKEYAMA Natsumi (財)日本生物科学研究所, 研究員 (20414089)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | プリオンタンパク質 / プリオン / エビジェネティクス / DNAメチル化 / プリオンタンパク質遺伝子 / マウス / エピジェネネティクス / プリオン蛋白遺伝子 / エピジェネティクス / 遺伝子メチル化 / 培養細胞 |
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| Outline of Final Research Achievements |
We analyzed the CpG methylation upstream of exon 1 in mouse prion protein gene. We show that the CpG island including promoter region in PrP gene is nonmethylated in all tissues. On the other hand, CpG methylation in upstream region adjacent to the CpG Island has occurred in various proportions.
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Report
(4 results)
Research Products
(4 results)
