| Project/Area Number |
24580452
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAI Shinji 北里大学, 獣医学部, 教授 (80137900)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | カンピロバクター / 食中毒 / 臓器移行 / 消化管内感染 / 鞭毛 / 病原性 / 糖鎖修飾 / カンピロバクター感染症 / 細胞侵入性 |
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| Outline of Final Research Achievements |
Campylobacter jejuni is a leading cause of bacterial food poisoning in Japan. Contaminated meat and viscera are major source of infection in human. It has been reported that C. jejuni transmits from the intestine to the viscera such as the liver. This might increase the risk of infection by C. jejuni because Japanese have the culture of eating the liver of cattle and chicken without heating them. However, mechanisms underlying C. jejuni survival and translocation in the hosts are still unknown. In this study, signature-tag transposon mutagenesis was carried out to identify C. jejuni genes that are necessary for survival and tlanslocation in the hosts. As results, it was suggested that the genes related to flagella, chemotaxis, capsule, N-linked glycosylation were necessary for infection by C.jejuni.
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