| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The purpose of this study is to establish a radical therapy of osteoarthritis by the cartilage regeneration medicine using bone marrow stromal cells (BMSCs) in dogs. Canine BMSCs could differentiated into cartilage-like structure using chondrogenic differentiation medium. The proliferative capacity of canine BMSCs that were cultured with serum-free medium was superior to that with conventional medium. However, chondrogenic potency of canine BMSCs that were cultured with serum-free medium was controversial. In this study, the mebiol gel was most suitable scaffold for canine artificial cultured cartilage. Finally, minimum invasive and optimal arthroscopic procedures for cartilage regeneration medicine could be established. These all results can contribute to the clinical application of cartilage regeneration medicine in dogs.
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