| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Obesity is a clinical problem in dogs. We explored genetic variants using genomic DNA samples collected from 141 dogs. We found 5 synonymous and 7 non-synonymous variants in the canine beta-3 adrenergic receptor gene, in which c.749C>T (p.Ser250Phe) was found more in obese dogs and c.1121C>G (p3Pro374Arg) was found more in lean dogs. We found 5 synonymous and 4 non-synonymous variants in the canine GPR120 gene, in which c.595C>A (p.Pro199Thr) was found more in obese dogs. The variant c.595C>A (p.Pro199Thr) was found only in beagles. These findings will be applied to clinical nutrition in dogs.
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