Characterization of feline microRNAs:a potential biomarker for diagnosis of feline diabetes and obesity

Research Project

Project/Area Number	24580468
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Clinical veterinary science
Research Institution	Nippon Veterinary and Life Science University
Principal Investigator	SASAKI NORIYASU 日本獣医生命科学大学, 獣医学部, 准教授 (20307979)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	マイクロRNA / ネコ / 肥満 / 糖尿病 / エクソソーム / バイオマーカー
Outline of Final Research Achievements	To characterize novel microRNAs (miRNA) related to obesity and diabetes in cats, we identified the feline miRNA expressed in white adipose tissue (WAT) and exosome with next-generation sequencing. In WAT, we identified 169 of novel feline miRNAs that could regulate expression of their target genes including angiogenesis, adipocyte differentiation and inhibition.