| Project/Area Number |
24580469
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
HARADA Yasuji 日本獣医生命科学大学, 獣医学部, 准教授 (70398882)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 再生医療 / 脊髄 / 骨髄 / 単核細胞 / 脊髄再生 / 獣医療 / 骨髄移植 |
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| Outline of Final Research Achievements |
As a regenerative therapy of a spinal cord, the various types of cell therapy were developed. Autologous transplantation of bone marrow-derived mononuclear cell is useful for early transplantation after injury without a cell culture. Our clinical trials, using an autologous transplantation of bone marrow-derived mononuclear cells, showed therapeutic effect for the spinal-cord-injury case of dogs. Since most mechanisms in which the transplanted bone marrow-derived mononuclear cell regenerate a spinal cord were not explored, we examined by using a rat model. As a result, the transplanted bone marrow-derived mononuclear cells existed in the injected area for over one week. Cytokines, such as HGF, MPC-1, and VEGF were secreted from transplanted bone marrow-derived mononuclear cells. These cytokines believed to reduce the apoptosis of nerve cells, and having a protective effect for injured spinal cord.
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