| Project/Area Number |
24580499
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Chubu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KUSUDO Tatsuya 中部大学, 生命健康科学部, 助手 (00460535)
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| Research Collaborator |
KATAOKA Naoya
LI Yongxue
KOJIMA Motoki
NOZAKI Aya
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 褐色脂肪細胞 / CREG1 / エネルギー代謝 / 肥満 / 代謝性疾患 / UCP1 |
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| Outline of Final Research Achievements |
Brown adipocytes dissipate caloric energy as heat, thereby being a potential therapeutic target in the battle against obesity and metabolic diseases. To clarify the mechanism of brown adipocyte differentiation, we investigated a number of candidate genes expected to be involved in the process and found a novel gene, cellular repressor of E1A-stimulated genes 1 (CREG1), coding a secreted glycoprotein. In adipocyte culture, Creg1 gene expression increased with the differentiation of brown adipocytes, which was also stimulated by addition of the purified protein. Administration of CREG1 protein stimulated brown adipocyte differentiation and improved fatty liver in mice. Our results suggest that CREG1 contributes to the regulation of whole body energy homeostasis as an endocrine molecule.
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