Asymmetric syntheses of biologically active heterocyclic natural products employing catalytic C-H activation strategy
| Project/Area Number |
24590001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
NAMBU Hisanori 富山大学, 大学院医学薬学研究部(薬学), 准教授 (80399956)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 複素環化合物 / C-H結合活性化 / 生物活性天然物 / C-H挿入反応 / 触媒反応 / ロジウム(II)錯体 / 不斉合成 / ジヒドロベンゾフラン / C-Hオレフィン化 / ロジウム(II)触媒 / ネオリグナン / スチルベンダイマー |
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| Outline of Final Research Achievements |
Asymmetric synthesis of (－)-trans-blechnic acid, a dihydrobenzofuran neolignan natural product, has been achieved by employing Rh(II)-catalyzed intramolecular C-H insertion reaction of aryldiazoacetate and Pd(II)-catalyzed intermolecular C-H olefination reaction as key steps.
Asymmetric synthesis of (－)-E-δ-viniferin, a trans-resveratrol dimer natural product containing a dihydrobenzofuran ring, has been achieved by exploiting Rh(II)-catalyzed intramolecular C-H insertion reaction of a diaryldiazomethane derivative as a key step.
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Report
(4 results)
Research Products
(16 results)
