| Project/Area Number |
24590005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
HIRANO Tomoya 東京医科歯科大学, 生体材料工学研究所, 准教授 (20396980)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 有機化学 / 分析科学 / 薬学 / 蛍光 / 分子イメージング / センサー / 生体関連物質 / 核内受容体 |
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| Outline of Final Research Achievements |
Fluorescent sensors, whose fluorescence properties are changed by each analyte, have been utilized in scientific research. For development of such sensors, we have constructed a library of fluorescent compounds. Form this library, sensor for the change of pH was developed, based on a structure containing two hydroxyl groups that are sequentially deprotonated as the pH increases: the first deprotonation increases the fluorescence intensity and the second decreases it. Compared with most reported pH sensors that can detect only whether the pH is below or above a specific value, our sensor could detect a specific range of pH. In addition, viscosity sensor, whose fluorescent maximum wavelength was sifted by the change of solvent viscosity, was also obtained. We also developed the sensors for metal cations like zinc or sodium ion, whose functions could be regulated by enzymatic reaction. Those sensors should be useful for the elucidation of physiological function and medical diagnosis.
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