A sustainable and enantioselective process based on chiral spiro-type catalysis
Project/Area Number |
24590009
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Chemical pharmacy
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Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 不斉 / スピロ / 環境調和 / 触媒 / 炭素-炭素結合形成 / キラル / エナンチオ選択的 / 環境低負荷型 / 四置換炭素 / 合成 / イオン性液体 |
Outline of Final Research Achievements |
Chiral ligands and organocatalysts with a spiro skeleton have received considerable attention in asymmetric catalysis because of their unique structural properties and high asymmetric induction efficiency. However, enantioselective synthesis of optically pure spirobicyclic compounds remains a formidable task because the chiral catalysts must control not only the enantiodiscrimination but also the formation of the quaternary carbon center. We have developed the facile synthesis of chiral spirobicycles through the Pd-catalyzed intramolecular α-arylation of α-substituted cyclic ketones. The absolute configuration of spirocyclic ketone was assigned as S by X-ray analysis.
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Report
(4 results)
Research Products
(53 results)
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[Presentation] Recent Progress in Pd-SPRIX Catalyses2013
Author(s)
Takenaka, K.; Mohanta, S. C.; Dhage, Y. D.; Takizawa, S.; Sasai, H.
Organizer
The 8th International Conference on Cutting-Edge Organic Chemistry in Asia and The 4th New Phase International Conference on S Cutting-Edge Organic Chemistry in Asia
Place of Presentation
Osaka, Japan
Related Report
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