Development and application of the cyclic carbon framework construction by the catalytic domino type reactions
Project/Area Number |
24590012
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Chemical pharmacy
|
Research Institution | Nagasaki University |
Principal Investigator |
KURIYAMA Masami 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (40411087)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 合成化学 / N-ヘテロ環状カルベン / パラジウム / 触媒反応 / 複素環 / N-ヘテロ環状カルベン / 遷移金属 / 炭素-炭素結合形成 / イミダゾール / カルベン / 骨格構築 / 連続反応 |
Outline of Final Research Achievements |
The development of efficient methods and effective ligands for catalytic synthesis of useful compounds was conducted. First, the one-pot synthetic method for ketones through palladium-catalyzed 1,2-addition and oxidation was achieved with the thioether-imidazolium chlorides. In this catalytic transformation, various monoheteroaryl and diheteroaryl ketones were prepared with high efficiency. Then, we developed novel ether-imidazolium chlorides as ligand precursors for transition metals. The palladium/ether-imidazolium chloride system realized the efficient synthesis of various biheteroaryls from heteroaryl chlorides and heteroaryl boron reagents.
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Report
(4 results)
Research Products
(15 results)