| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The development of efficient methods and effective ligands for catalytic synthesis of useful compounds was conducted. First, the one-pot synthetic method for ketones through palladium-catalyzed 1,2-addition and oxidation was achieved with the thioether-imidazolium chlorides. In this catalytic transformation, various monoheteroaryl and diheteroaryl ketones were prepared with high efficiency. Then, we developed novel ether-imidazolium chlorides as ligand precursors for transition metals. The palladium/ether-imidazolium chloride system realized the efficient synthesis of various biheteroaryls from heteroaryl chlorides and heteroaryl boron reagents.
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