| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
I have developed a new method for the preparation of optically active tetrasubstituted allenes. In the presence of AgOTf, the reaction of tertiary propargyl alcohols with an ynamide, followed by the [3,3]-sigmatropic rearrangement, proceeded under mild conditions to afford tetrasubstituted allenes. The central chirality of propargyl alcohols was completely transferred into the axial chirality of allenes.
The platinum-catalyzed intramolecular cyclization of the formed allenes provided polysubstituted indene derivatives, bearing a quaternary stereogenic carbon center, in high yields and with the axial-to-central chirality transfer. Moreover, the reaction using the combination of platinum catalysts and AgOTf allowed for the formation of multisubstituted unsaturated lactones.
This methodology was applied to the synthetic study of bioactive natural products.
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