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Synthetic Studies on Biological Active Natural Products Directed Toward Developing Novel Molecular-Targeted Agents

Research Project

Project/Area Number 24590017
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Chemical pharmacy
Research InstitutionTohoku Pharmaceutical University

Principal Investigator

KATOH Tadashi  東北薬科大学, 薬学部, 教授 (50382669)

Co-Investigator(Kenkyū-buntansha) WATANABE Kazuhiro  東北薬科大学, 薬学部, 講師 (10382673)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords分子標的治療薬 / 生物活性天然物 / 抗腫瘍活性物質 / 全合成 / TAN-1813 / HDAC阻害剤 / FK228 / スピルコスタチン
Outline of Final Research Achievements

In the course of our synthetic studies on a novel p21ras farnesyltransferase inhibitor, TAN-1813, a new method for construction of maleimide and a new coupling reaction of maleimide using phenylthio group as a leaving group were successfully developed. The reaction was applied to the coupling reaction of the maleimide segment with the decalin segment, which afforded the advanced key intermediate possessing whole carbon skeleton with all asymmetric carbon centers and functional groups present in the natural product.
A new synthetic route for the synthesis of FK228 analogues as novel HDAC inhibitors, was developed in a highly convergent and unified manner. Eight analogues were synthesized, and their biological evaluation disclosed novel aspects of structure-activity relationships. Further investigation of FK228 analogues identified FK-A11 as a promising candidates for novel anticancer agent. FK-A11 is currently conducting preclinical studies in Tohoku University Hospital.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (56 results)

All 2015 2014 2013 2012 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results,  Acknowledgement Compliant: 4 results,  Open Access: 1 results) Presentation (35 results) (of which Invited: 1 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Biochemical, biological and structural properties of romidepsin (FK228) and its analogs as novel HDAC/PI3K dual inhibitors.2015

    • Author(s)
      2.Saijo, K.,Imamura, J.,Narita, K.,Oda, A.,Shimodaira, H.,Katoh, T.,Ishioka, C.
    • Journal Title

      Cancer Sci

      Volume: 106 Issue: 2 Pages: 208-215

    • DOI

      10.1111/cas.12585

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Directed synthesis of 2–spiroindolines from indole derivatives by formic acid-induced N–acyliminium ion-conjugated diene spirocyclization2015

    • Author(s)
      Hideki Abe, Naohiro Miyagawa, Sho Hasegawa, Toyoharu Kobayashi, Sakae Aoyagi, Chihiro Kibayashi, Tadashi Katoh, Hisanaka Ito
    • Journal Title

      Tetrahedron Lett.

      Volume: 56 Issue: 7 Pages: 921-924

    • DOI

      10.1016/j.tetlet.2014.12.130

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biogenetically Inspired Total Synthesis of (+)-Liphagal: A Potent and Selective Phosphoinositide 3-Kinase α (PI3Kα) Inhibitor from the Marine Sponge Aka coralliphaga2014

    • Author(s)
      Takaaki Kamishima, Takuya Kikuchi, Koichi Narita, Tadashi Katoh
    • Journal Title

      Eur. J. Org. Chem.

      Volume: - Issue: 16 Pages: 3443-3450

    • DOI

      10.1002/ejoc.201402082

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Spiruchostatin A and B, Novel Histone Deacetylase Inhibitors, Induce Apoptosis through Reactive Oxygen Species-Mitochondria Pathway in Human Lymphoma U937 Cells2014

    • Author(s)
      Mati Ur Rehman, Paras Jawaid, Yoko Yoshihisa, Peng Li, Qing Li Zhao, Koichi Narita, Tadashi Katoh, Takashi Kondo, Tadamichi Shimizu
    • Journal Title

      Chem. -Biol. Interact.

      Volume: 221 Pages: 24-34

    • DOI

      10.1016/j.cbi.2014.07.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predicting the structures of complexes between phosphoinositide 3-kinase (PI3K) and romidepsin-related compounds for the drug design of PI3K/histone deacetylase dual inhibitors using computational docking and the ligand-based drug design approach.2014

    • Author(s)
      Oda, A.,Saijo, K.,Ishioka, C.,Narita, K.,Katoh, T.,Watanabe, Y.,Fukuyoshi, S.,Takahashi, O.
    • Journal Title

      J Mol Graph Model

      Volume: 54 Pages: 46-53

    • DOI

      10.1016/j.jmgm.2014.08.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis of β-Lapachone, a Potential Anticancer Agent from the Lapacho Tree2014

    • Author(s)
      Takeru Katoh, Hiromitsu Monma, Jun Wakasugi, Koichi Narita, Tadashi Katoh
    • Journal Title

      Eur. J. Org. Chem.

      Volume: - Issue: 32 Pages: 7099-7103

    • DOI

      10.1002/ejoc.201403064

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Enantioselective Total Synthesis of Dysidavarone A, a Novel Sesquiterpenoid Quinone from the Marine Sponge Dysidea avara2014

    • Author(s)
      Yurie Fukui, Koichi Narita, Tadashi Katoh
    • Journal Title

      Chem. Eur. J.

      Volume: 86 Issue: 9 Pages: 2436-2439

    • DOI

      10.1002/chem.201304809

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of Burkholdacs A and B and 5,6,20-Tri-epi-burkholdac A: HDAC Inhibition and Antiproliferative Activity2014

    • Author(s)
      Yurie Fukui, Koichi Narita, Singo Dan, Takao Yamori, Akihiro Ito, Minoru Yoshida, Tadashi Katoh
    • Journal Title

      Eur. J. Med. Chem.

      Volume: 76 Pages: 301-313

    • DOI

      10.1016/j.ejmech.2014.02.044

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities.2013

    • Author(s)
      Narita K, Fukui Y, Sano Y, Yamori T, Ito A, Yoshida M, Katoh T.
    • Journal Title

      Eur J Med Chem.

      Volume: 60 Pages: 295-304

    • DOI

      10.1016/j.ejmech.2012.12.023

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of (+)-Strongylin A, a Rearranged Sesquiterpenoid Hydroquinone from a Marine Sponge2013

    • Author(s)
      Takaaki Kamishima, Takuya Kikuchi, Tadashi Katoh
    • Journal Title

      Eur. J. Org. Chem.

      Volume: - Issue: 21 Pages: 4558-4563

    • DOI

      10.1002/ejoc.201300438

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enantioselective Total Synthesis of Otteliones A and B, Novel and Powerful Antitumor Agents from The Freshwater Plant Ottelia alismoides2013

    • Author(s)
      Tadashi Katoh
    • Journal Title

      Nat. Prod. Commun.

      Volume: 8 Pages: 973-980

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of Decahydrobenzo[d]xanthene Sesquiterpenoids Aureol, Strongylin A, and Stachyflin: Development of a New Strategy for the Construction of a Common Tetracyclic Core Structure2013

    • Author(s)
      Tadashi Katoh
    • Journal Title

      Heterocycles

      Volume: 87 Issue: 11 Pages: 2199-2224

    • DOI

      10.3987/rev-13-779

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Deprotection of 3, 4-Dimethoxybenzyl(^<3, 4> DMB) Group onγ-Lactam Nitrogen Using Phenyliodine(III) Bis(trifluoroacetate)(PIFA): Application to Isoindolinone C ompounds2012

    • Author(s)
      Kazuhiro Watanabe, Hiroaki Shibata, Y. Imai, Tadashi Katoh
    • Journal Title

      Heterocycles

      Volume: 84巻 Issue: 2 Pages: 1355-1361

    • DOI

      10.3987/com-11-s(p)77

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of p21waf/cip1 Expression in the Cytotoxicity of the Potent Histone Deacetylases Inhibitor Spiruchostatin B Towards Susceptible NALM-6 Human B Cell Leukemia Cells2012

    • Author(s)
      Syu-ichi Kanno, Naoyuki Maeda, Aayako Tomizawa, Shin Yomogida, Tadashi Katoh, Masaaki Ishikawaichi
    • Journal Title

      Int. J. Oncol.

      Volume: 40 Pages: 1391-1396

    • DOI

      10.3892/ijo.2011.1323

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of cells resistant to the potent histone deacetylase inhibitor spiruchostatin B (SP-B) and effect of overexpressed p21waf1/cip1 on the SP-B resistance or susceptibility of human leukemia cells.2012

    • Author(s)
      Kanno S, Maeda N, Tomizawa A, Yomogida S, Katoh T, Ishikawa M.
    • Journal Title

      Int J Oncol.

      Volume: Vol. 40(5) Issue: 3 Pages: 1391-6

    • DOI

      10.3892/ijo.2012.1507

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Romidepsin (FK228) and its analogs directly inhibit PI3K activity and potently induce apoptosis as HDAC/PI3K dual inhibitors2012

    • Author(s)
      Ken Saijo, Tadashi Katoh, Hideki Shimodaira, Akifumi Oda, Ohgi Takahashi, Chikashi Ishioka
    • Journal Title

      Cancer Science

      Volume: 103 Issue: 11 Pages: 1994-2001

    • DOI

      10.1111/cas.12002

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A New Entry to the Synthesis of Primin via a B-Alkyl Suzuki–Miyaura Cross-Coupling Reaction2012

    • Author(s)
      Kazuhiro Watanabe, Tomohiro Sugizaki, Yumi Tozawa, Tadashi Katoh
    • Journal Title

      Heterocycles

      Volume: 86 Issue: 2 Pages: 985-989

    • DOI

      10.3987/com-12-s(n)104

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] PTP1B 阻害活性を有するダイシダバロン B および C の全合成研究2015

    • Author(s)
      成田紘一, 福井友理恵, 佐藤江里, 安達剛史, 加藤 正
    • Organizer
      日本薬学会第 135 年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] カンナビノイド受容体アゴニスト活性を有するフェルギネン B の全合成研究2015

    • Author(s)
      佐々木 理, 成田紘一, 加藤 正
    • Organizer
      日本薬学会第 135 年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 海洋天然物であるイリマキノン、イソスポンジアキノン、スメノクアロンおよび スメノスポンジンの全合成2015

    • Author(s)
      加藤 武, 熱海 秀, 佐藤廣河, 平間美佳, 成田紘一, 加藤 正
    • Organizer
      日本薬学会第 135 年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 選択的 PI3Kα 阻害物質(+)-リファガールの全合成2015

    • Author(s)
      菊地拓也, 神島尭明, 成田紘一, 加藤 正
    • Organizer
      日本薬学会第 135 年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] PTP1B 阻害活性を有する ダイシダバロン A の全合成2014

    • Author(s)
      福井友理恵,成田紘一,加藤 正
    • Organizer
      第 40 回 反応と合成の進歩シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] p21ras ファルネシルトランスフェラーゼ阻害物質 TAN-1813 の合成研究2014

    • Author(s)
      成田紘一,加藤 正
    • Organizer
      第 53 回日本薬学会東北支部大会
    • Place of Presentation
      いわき
    • Year and Date
      2014-10-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新規 HDAC/PI3K 二重阻害剤としてのデプシペプチド類縁体の抗腫瘍活性の検討2014

    • Author(s)
      西條 憲,李 仁,成田 紘一,加藤 正,下平 秀樹,石岡 千加史
    • Organizer
      第 73 回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] In vitro および in vivo における PI3K/HDAC 二重阻害剤としての FK228 類縁体の抗腫瘍効果の評価2014

    • Author(s)
      李 仁,西條 憲,下平秀樹,成田紘一,加藤 正,石岡千加史
    • Organizer
      第 18 回日本がん分子標的治療学会
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] In Vitro and In Vivo Antitumor Effects of Romidepsin Analogs as Novel PI3K/HDAC dual Inhibitors2014

    • Author(s)
      Jin Lee,Ken Saijo, Koichi Narita, Tadashi Katoh, Hideki Shimodaira, Chikashi Ishioka
    • Organizer
      The 9th International Symposium of the Institute Network
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] PTP1B 阻害活性を有する ダイシダバロン A の全合成2014

    • Author(s)
      福井友理恵,成田紘一,加藤 正
    • Organizer
      平成 26 年度 東北薬科大学 創薬研究センターシンポジウム:衛生毒性学の最先端研究から創薬への提言
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 抗芽腫治療薬の創製を指向したセスキテルペンキノンおよびセスキテルペンベンゾオキサゾール類の合成研究2014

    • Author(s)
      熱海 秀,加藤 武,成田紘一,加藤 正
    • Organizer
      平成 26 年度 東北薬科大学 創薬研究センターシンポジウム:衛生毒性学の最先端研究から創薬への提言
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 抗インフルエンザ活性を有するストロンギリンAの全合成2013

    • Author(s)
      神島 尭明, 渡邉 一弘, 加藤 正
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 抗腫瘍活性を有するダイシダバロンAの全合成研究2013

    • Author(s)
      福井友理恵, 成田紘一 加藤 正
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] ジベンゾ[b,f]オキセピン骨格を有するバウヒノキセピンHの全合成研究2013

    • Author(s)
      成田紘一, 加藤 正
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] リパーゼによる位置選択的な脱アセチル化反応を基軸とする (Z)-4-ヒドロキシタモキシフェンの合成2012

    • Author(s)
      渡邉一弘,伊藤拓也,加藤亜沙美,千田一慶,加藤 正
    • Organizer
      東北薬科大学 創薬研究センターシンポジウム-癌・加齢性疾患研究の臨床展開-
    • Place of Presentation
      東北薬科大学
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒストン脱アセチル化酵素(HDAC)阻害剤ブルクホルダック A の全合成2012

    • Author(s)
      福井友理恵,成田紘一,加藤 正
    • Organizer
      東北薬科大学 創薬研究センターシンポジウム-癌・加齢性疾患研究の臨床展開-
    • Place of Presentation
      東北薬科大学
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒストン脱アセチル化酵素 (HDAC) 阻害剤 ブルクホルダック A の全合成2012

    • Author(s)
      福井友理恵,成田紘一,加藤 正
    • Organizer
      第 51 回日本薬学会東北支部大会,青森
    • Place of Presentation
      青森
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒストン脱アセチル化酵素(HDAC)阻害剤ブルクホルダック A の全合成2012

    • Author(s)
      福井友理恵,成田紘一,加藤 正
    • Organizer
      第 38 回反応と合成の進歩シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 新規 HDAC/PI3K 2 重阻害剤としてのロミデプシン (FK228) 類縁体の同定2012

    • Author(s)
      西條 憲, 加藤 正,石岡千加史
    • Organizer
      第 16 回日本がん分子標的治療学会
    • Place of Presentation
      北九州
    • Related Report
      2012 Research-status Report
  • [Presentation] Prediction of the Complex Structure between PI3K and Romidepsin (FK228) for Drug Desing of PI3K/HDAC Dual Inhibitors2012

    • Author(s)
      Akifumi Oda, Ken Saijo, Chikashi Ishioka, Tadashi Katoh, Shuichi Fukuyoshia, Ryoichi Nakagaki, Ohgi Takahashi
    • Organizer
      生命医薬情報学連合大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 分子内に S-S 結合を持つ大環状デプシペプチド類の合成と活性評価

    • Author(s)
      加藤 正
    • Organizer
      文部科学省新学術領域研究「がん研究分野の特性等を踏まえた支援活動」化学療法基盤支援活動班・ミニ班会議
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 抗インフルエンザAウイルス活性を有するストロンギリンAの全合成

    • Author(s)
      神島尭明,加藤 正
    • Organizer
      平成 25 年度 東北薬科大学 創薬研究センターシンポジウム:合成化学と創薬研究のクロスオーバー
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] スピルコスタチン類の全合成とそのHDAC阻害およびヒトがん細胞増殖抑制活性の評価

    • Author(s)
      福井友理恵,成田紘一,加藤 正
    • Organizer
      平成 25 年度 東北薬科大学 創薬研究センターシンポジウム:合成化学と創薬研究のクロスオーバー
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] HDAC/PI3K Dual Inhibitor としての Romidepsin (FK228) 新規類縁体の開発と最適化

    • Author(s)
      李 仁,西條 憲, 下平秀樹,成田紘一,加藤 正,石岡千加史
    • Organizer
      第 17 回日本がん分子標的治療学会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] The First Total Synthesis of (+)-Strongylin A; A Potential Anti-Influenza A Virus Agent

    • Author(s)
      Takaaki Kamishima, Tadashi Katoh
    • Organizer
      13th International Conference on the Chemistry of Antibiotics and other bioactive compounds (ICCA-13)
    • Place of Presentation
      Yamanashi, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Synthetic Study Toward Marine Natural Products Related to Illimaquione

    • Author(s)
      Suguru Atsumi, Koichi Narita, Tadashi Katoh
    • Organizer
      13th International Conference on the Chemistry of Antibiotics and other bioactive compounds (ICCA-13)
    • Place of Presentation
      Yamanashi, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Total Synthesis of the Bicyclic Depsipeptides -Spiruchostatins A, B, C and D- and Investigation of Their HDAC inhibitory and Antiproliferative Activities

    • Author(s)
      Yurie Fukui, Koichi Narita, Tadashi Katoh
    • Organizer
      13th International Conference on the Chemistry of Antibiotics and other bioactive compounds (ICCA-13)
    • Place of Presentation
      Yamanashi, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] 抗インフルエンザAウイルス活性を有するストロンギリンAの全合成

    • Author(s)
      神島尭明,加藤 正
    • Organizer
      第 52 回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] 抗腫瘍活性を有するダイシダバロンAの全合成

    • Author(s)
      福井友理恵,成田紘一,加藤 正
    • Organizer
      第 52 回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] p21 ras ファルネシルトランスフェラーゼ阻害物質 TAN-1813 の合成研究

    • Author(s)
      成田紘一,加藤 正
    • Organizer
      第 52 回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] 抗インフルエンザAウイルス活性を有するストロンギリンAの全合成

    • Author(s)
      神島尭明,加藤 正
    • Organizer
      第 39 回 反応と合成の進歩シンポジウム
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] Enhancement of Radiation-Induced Apoptosis by a Potent Histone Deacetylase Inhibitor Spiruchoustatin-B

    • Author(s)
      Mati ur Rehman, Paras Jawaid, Koichi Narita, Tadashi Katoh, Tadamichi Shimizu, Takashi Kondo
    • Organizer
      The 1 st GI-CORE Medical Science and Engineering Symposium
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] 抗腫瘍活性を有する ダイシダバロン A の全合成

    • Author(s)
      福井友理恵,成田紘一,加藤 正
    • Organizer
      日本薬学会第 134 年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] p21 ras ファルネシルトランスフェラーゼ阻害物質 TAN-1813 の合成研究

    • Author(s)
      成田紘一,加藤 正
    • Organizer
      日本薬学会第 134 年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] 抗腫瘍活性を有するβ-ラパコンの簡便合成

    • Author(s)
      加藤武,門間博充,若杉潤,成田紘一,加藤 正
    • Organizer
      日本薬学会第 134 年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Book] Studies in Natural Products Chemistry2014

    • Author(s)
      Tadashi Katoh, ed. by Atta-ur-Rahman
    • Total Pages
      39
    • Publisher
      Elsevier
    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北薬科大学 医薬合成化学教室ホームページ

    • URL

      http://www.tohoku-pharm.ac.jp/laboratory/iyakugo/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北薬科大学 医薬合成化学教室ホームページ

    • URL

      http://www.tohoku-pharm.ac.jp/laboratory/iyakugo/index.html

    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 新規ホスファチジルイノシトール3キナーゼ阻害剤及び医薬組成物2012

    • Inventor(s)
      西絛 憲、石岡千加史、加藤 正
    • Industrial Property Rights Holder
      西絛 憲、石岡千加史、加藤 正
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-09-25
    • Related Report
      2012 Research-status Report
    • Overseas

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Published: 2013-05-31   Modified: 2019-07-29  

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