Development of catalytic reactions based on the properties of nonmetallic elements
| Project/Area Number |
24590018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | FLPs / 有機ホウ素化合物 / 触媒的水素化反応 / 水素固定 / 触媒的不斉水素化反応 |
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| Outline of Final Research Achievements |
The synthesis of the designed organoboron compounds and their reactivity for molecular hydrogen were examined. Although triaryl boron compounds bearing bis(pentafluorophenyl) boryl group were highly unstable against air (molecular oxygen) and water, we demonstrated that the introduction of a coordinating group such as pyridine, amide, formyl, or ether to ortho position of aryl bis(pentafluorophenyl)boron increased chemical stabilities and enabled to handle under air. The synthesized organoboron compounds showed no reactivity for molecular hydrogen under various conditions. However, the ether type organoboron compounds with methoxymethyl ether at ortho position indicated the reversibility of the coordination of an ether oxygen atom toward boron(III) center. These observations serve as a guiding principle of catalyst design for hydrogenation reaction.
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Report
(4 results)
Research Products
(44 results)
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[Presentation] マイクロフロー経路内における効率的なオレアノール酸C3 位配糖化の検討2015
Author(s)
小西成樹, 白畑辰弥, 永井隆之, 清原寛章, 平田望, 横山将来, 勝見達也, 西野貴司, 牧野一石, 山田陽城, 梶英輔, 小林義典
Organizer
日本薬学会第135年会
Place of Presentation
神戸学院大学（神戸）
Year and Date
2015-03-25 – 2015-03-28
Related Report
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