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Studies on the various biological functions of the edible plants at the molecular level

Research Project

Project/Area Number 24590022
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Chemical pharmacy
Research InstitutionTokai University

Principal Investigator

ONO Masateru  東海大学, 農学部, 教授 (60177269)

Co-Investigator(Kenkyū-buntansha) YASUDA Shin  東海大学, 農学部, 准教授 (10512923)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords食用植物 / ブラックベリー / クサギ / サツマイモ / モリンガ / トマト / 成分 / 生物活性 / 抗酸化活性 / 抗炎症活性 / がん細胞増殖抑制活性 / 生物活性成分 / 機器分析 / 化学構造 / 抗動脈硬化活性
Outline of Final Research Achievements

For the elucidation of the various biological functions of the edible plants, we studied the constituents from the fruits, leaves, and seeds of Rubus allegheniensis, the leaves of Clerodendrum trichotomum, the tubers of Ipomoea batatas, the leaves and petioles of Moringa oleifera, and the fruits of Solanum lycopersicum. These studies resulted in the isolation of 53 compounds including five new compounds from their methanol extracts by using the various chromatographies. In addition, their chemical structures were elucidated on the basis of chemical and instrumental analyses data. Furthermore, various biological activities, e.g. anti-oxidative and anti-inflammatory activities, of the extracts , the separated fractions, and some isolates were examined.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (5 results)

  • [Journal Article] A new hemiterpene glycoside from the ripe tomatoes2015

    • Author(s)
      M. Ono, S. Yasuda, Y. Shiono, C. Furusawa, S. Inaba, T. Tanaka, T. Ikeda, T. Nohara
    • Journal Title

      Nat. Prod. Res.

      Volume: 29 Issue: 3 Pages: 262-267

    • DOI

      10.1080/14786419.2014.974053

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Triterpenoids from the Fruits and Leaves of the Blackberry (Rubus allegheniensis) and Their Inhibitory Activities on Foam Cell Formation in Human Monocyte-Derived Macrophage2014

    • Author(s)
      M. Ono, S. Yasuda, H. Komatsu, Y. Fujiwara, M. Takeya, T. Nohara
    • Journal Title

      Nat. Prod. Res.

      Volume: 28 Issue: 24 Pages: 839-844

    • DOI

      10.1080/14786419.2014.939087

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A new diterpenoid from the leaves of Clerodendron trichotomum2013

    • Author(s)
      M. Ono, C. Furusawa, K. Matsumura, S. Noguchi, S. Yasuda, M. Okawa, J. Kinjo, M. Eto, K. Yamaguchi, H. Yoshimitsu. T. Nohara
    • Journal Title

      J. Nat. Med.

      Volume: 67 Issue: 2 Pages: 404-409

    • DOI

      10.1007/s11418-012-0690-7

    • NAID

      40019609247

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ワサビノキ(Moringa oleifera)の葉と葉柄の成分に関する研究2014

    • Author(s)
      鈴木宏明、西岡 峻、西田陽一郎、安田 伸、永井竜児、長野克也、池嵜陽子、岡田誠治、大川雅史、金城順英、吉満 斉、野原稔弘、小野政輝
    • Organizer
      平成26年度日本栄養・食糧学会九州・沖縄支部大会
    • Place of Presentation
      熊本県立大学(熊本県熊本市)
    • Year and Date
      2014-10-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] サツマイモ‘ムラサキマサリ’塊根の樹脂配糖体に関する研究2014

    • Author(s)
      山野裕貴、寺本世生、内藤沙織、安田 伸、多賀直彦、椛田聖孝、大川雅史、金城順英、吉満 斉、野原稔弘、小野政輝
    • Organizer
      平成26年度日本栄養・食糧学会九州・沖縄支部大会
    • Place of Presentation
      熊本県立大学(熊本県熊本市)
    • Year and Date
      2014-10-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] ブラックベリー(Rubus fructicosus)種子の成分に関する研究(2)2014

    • Author(s)
      樋口智美、西 香織、川添真希、渕崎哲史、小松春喜、大川雅史、金城順英、吉満 斉、野原稔弘、安田 伸、小野政輝
    • Organizer
      平成26年度日本栄養・食糧学会九州・沖縄支部大会
    • Place of Presentation
      熊本県立大学(熊本県熊本市)
    • Year and Date
      2014-10-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] ブラックベリー(Rubus allegheniensis)種子の成分に関する研究2014

    • Author(s)
      小野政輝,西 香織、安田 伸、小松春喜、大川雅史、金城順英、吉満 斉、野原稔弘
    • Organizer
      第61回日本生薬学会
    • Place of Presentation
      福岡大学(福岡県福岡市)
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] ブラックベリー(Rubus allegheniensis)の成分に関する研究(3)2012

    • Author(s)
      山本和孝、髙良真樹子、小松春喜、藤原章雄、竹屋元裕、野原稔弘、小野政輝
    • Organizer
      平成24年度日本農芸化学会西日本支部および日本栄養・食糧学会九州・沖縄支部合同大会
    • Place of Presentation
      鹿児島大学
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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