| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Bioactive polyfunctionalized cyclic terpenoid has much attention on developing of medicine. Synthetic study of terpenoid which having complex carbon skeleton is very important for clarify the structure-activity relationship. Synthetic study of two terpenoids, albaflavenone and aberrarone, which having complex and interesting carbon skeleton, was examined. Total synthesis of albaflavenone, antibiotic sesquiterpene, has been accomplished via the concise construction of skeleton utilizing sequential intramolecular aldol condensation. This synthetic work was completed in nine steps without the use of protecting groups and with high stereocontrol. Highly stereocontrolled synthesis of the tetracyclic core of diterpenoid aberrarone, which possesses antimalarial activity, has also been accomplished. A key feature of the synthesis is the complete stereocontrolled construction of C- and D-ring using stereoselective 1,4-addition followed by intramolecular aldol reaction.
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