Study on crude drugs aimed at prevention and improvement of intractable diseases related
Project/Area Number |
24590028
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Chemical pharmacy
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Research Institution | Nihon University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Tomonori 慶応大学, 薬学部, 教授 (30251151)
|
Co-Investigator(Renkei-kenkyūsha) |
KUSAMA Kuniko 日本大学, 薬学部, 教授 (10130436)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 糖尿病 / 神経保護 / アルツハイマー / フラバノノール誘導体 / 小胞体ストレス / 筋委縮性側索硬化症 / マクロファージ / アルツハイマー病 / adiponectin |
Outline of Final Research Achievements |
Flavanonol derivative, aromadendrin, obtained from white peach flowers was increasied by the secretion of adipocain using murine preadipocytes 3T3-L1. Result of tunicamycin-induced endoplasmic reticulumstress inhibitory activity test using HT22 cells from the hippocampus of these compounds, two flavanonols showed high inhibitory activity. From Rhodiola sacra, 2-phenylethyl gallate was isolated as a compound to inhibit the activation of macropharges, and evaluated four synthesized compounds. As a result, strongest activity was observed in the compound with four methylene groups. For the purpose of neuroprotective component, a new alkaloid effususol A was extracted and isolated from Licopodium serratum var. longipetiolatum.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Molecular phlogenetics and character evolution of morphologically diverse groups, Dendrobium section Dendrobium and allies2014
Author(s)
Tomoko Takamiya, Shunichiro Suzuki, Saki Kitamura, Nao Shioda, Susumu Kitanaka, Hiroshi Iijima, Pheraut Wongsawad, Natsuko Tajima, Apirada Sathapattayanon Apirada, Takashi Handa, Tomohisa Yukawa
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Journal Title
AoB plants
Volume: 2014
Issue: 3
Pages: 1-25
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effects of ultrahigh pressure extraction condition on yields of berberine and palmatine from cortex Phellodendri amurensis2013
Author(s)
Shun Liu, Yan Chen, Lijuan Gu, Yongxia Li, Bingyi Wang, Jie Hao, Hui Zhu, Heran Li, Shilin Yang, Susumu Kitanaka,
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Journal Title
Analytical Methods
Volume: 5
Pages: 4506-4512
Related Report
Peer Reviewed
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