| Project/Area Number |
24590028
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Tomonori 慶応大学, 薬学部, 教授 (30251151)
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| Co-Investigator(Renkei-kenkyūsha) |
KUSAMA Kuniko 日本大学, 薬学部, 教授 (10130436)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 糖尿病 / 神経保護 / アルツハイマー / フラバノノール誘導体 / 小胞体ストレス / 筋委縮性側索硬化症 / マクロファージ / アルツハイマー病 / adiponectin |
|---|
| Outline of Final Research Achievements |
Flavanonol derivative, aromadendrin, obtained from white peach flowers was increasied by the secretion of adipocain using murine preadipocytes 3T3-L1. Result of tunicamycin-induced endoplasmic reticulumstress inhibitory activity test using HT22 cells from the hippocampus of these compounds, two flavanonols showed high inhibitory activity. From Rhodiola sacra, 2-phenylethyl gallate was isolated as a compound to inhibit the activation of macropharges, and evaluated four synthesized compounds. As a result, strongest activity was observed in the compound with four methylene groups. For the purpose of neuroprotective component, a new alkaloid effususol A was extracted and isolated from Licopodium serratum var. longipetiolatum.
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