| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
We had found dynamic kinetic resolution reaction, which proceeded via pi-allylpalladium complex including unusual carbon-carbon bond formation reaction. Thus, we have started our research to establish the optimized reaction condition and utilize its product for the enantioselective synthesis of biologically active compounds as our object.
As results, we established the synthetic route of the starting material and clarified a requirement of the substrate to obtain high enantioselectivity. Moreover, we successfully optimized the solvent and reaction temperature, and established to generate chiral Pd(0) complex in situ. Although we also clarified both of chemical yields and enantioselectivity are influenced by the electronic effect of the substituent on the aromatic ring, elusidation of the mechanism for DKR is underway. By the way, we successfully achieved the stereoselective construction of the chiral quaternary carbon center on benzylic position.
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