| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Gymnocin-A was isolated from a culture of red-tide dinoflagellate Karenia mikimotoi. The structure of gymnocin-A is characterized by a stunning array of 14 contiguous ether rings and shows cyctotoxic activity against P388 mouse leukemia cells.
The synthetic studies toward the total synthesis of gymnocin-A have been carried out. In this study, synthesis of the three ABC-, FGH-, and KLMN-ring fragments was achieved in a convergent manner. The key feature of this approach is carbon-carbon bond formation by an oxiranyl anion coupling, which was followed by intramolecular Williamson ether synthesis and the reductive etherification of an cyclic acetal.
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