| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Acetogenin is a class of polyketides of natural product obtained from Annonaceous plants. Although they exhibit diverse bioactivities, potent antitumor activity has particular attracted. Goniocin was isolated from a bark part of Goniothalamus giganteus in Thailand and has exhibited potent cytotoxic activity against several tumor cell lines at a level of nano molar. Goniocin is only a natural compound to possess a contiguous all trans-tris-THF ring system that consists of trans-threo-trans-threo-trans stereochemistry. In this research, the chemical total synthesis of this natural product has been accomplished.
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