Iodocyclization of ynamides
| Project/Area Number |
24590038
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | イナミド / 環化反応 / ヨウ素 / 複素環 |
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| Outline of Final Research Achievements |
Ynamides are useful synthons because they exhibit high reactivity toward electrophiles and can be adapted to asymmetric reactions if ynamides are chiral. Therefore, I have developed the iodocyclization of ynamides: for examples, benzofuran synthesis was achieved within three seconds in milder reaction conditions than using normal alkynes. In addition, 6-endo type iodocyclization of homopropargylic hydrazides as substrates proceeded by using ynamides to afford dihydropyridazines. Furthermore, tandem dearomative iodocyclization/ Diels-Alder reaction and polyene cyclization using chiral ynamides were demonstrated in diastereoselective manner to obtain optically active spiro rings and tricyclic skeletons.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Solid-state NMR spectroscopy structure determination of a lipid-embedded heptahelical membrane protein2013
Author(s)
Wang, S.; Munro, R. A.; Shi, L.; Kawamura, I.; Okitsu, T.; Wada, A.; Kim, S.-Y.; Jung, K.-H.; Brown, L. S.; Ladizhansky, V.
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Journal Title
Nature Methods
Volume: 10(10)
Issue: 10
Pages: 1007-1012
DOI
Related Report
Peer Reviewed
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[Journal Article] Large spectral change due to amide modes of a β-sheet upon the formation of an early photointermediate of middle rhodopsin2013
Author(s)
Furutani, Y., Okitsu, T., Reissig, L., Mizuno, M., Homma, M., Wada, A., Mizutani, Y., Sudo, Y.
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Journal Title
J. Phys. Chem. B
Volume: 117
Issue: 13
Pages: 3449-3458
DOI
Related Report
Peer Reviewed
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