Development of domino reactions utilizing unique property of N-alkoxy-amides and imines
| Project/Area Number |
24590039
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Kobe Pharmaceutical University |
|---|
Principal Investigator |
UEDA Masafumi 神戸薬科大学, 薬学部, 准教授 (00340935)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | ドミノ反応 / ラジカル / オキシム / ヒドラゾン / ヘテロ環 / 遷移金属触媒 / ラジカル反応 / Fischerインドール合成 / 共役ヒドラゾン / 複素環合成 / Weinreb アミド / イソキサゾール / 共役イミン |
|---|
| Outline of Final Research Achievements |
Domino reactions are greener reactions that allow for complex molecules to be constructed from a simple substrate in one operation in a straightforward, efficient, and elegant way without isolation of intermediates. The domino reaction of O-phenyl-conjugated oxime ether with an alkyl radical allows the construction of two heterocycles with three stereogenic centers as a result of the formation of two C-C bonds, a C-O bond, and a C-N bond in a single operation, leading to benzofuro[2,3-b]pyrroles, which are not easily accessible by existing synthetic methods. In addition, we also developed that a new method for the synthesis of isoquinolinones involving the palladium-catalyzed cyclization reaction.
|
Report
(4 results)
Research Products
(21 results)
