| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Domino reactions are greener reactions that allow for complex molecules to be constructed from a simple substrate in one operation in a straightforward, efficient, and elegant way without isolation of intermediates. The domino reaction of O-phenyl-conjugated oxime ether with an alkyl radical allows the construction of two heterocycles with three stereogenic centers as a result of the formation of two C-C bonds, a C-O bond, and a C-N bond in a single operation, leading to benzofuro[2,3-b]pyrroles, which are not easily accessible by existing synthetic methods. In addition, we also developed that a new method for the synthesis of isoquinolinones involving the palladium-catalyzed cyclization reaction.
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