| Project/Area Number |
24590040
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Fukuyama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
CHOSHI Tominari 福山大学, 薬学部, 教授 (10248297)
HATAE Noriyuki 北海道医療大学, 薬学部, 准教授 (30449912)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | マイクロ波照射下アザ電子環状反応 / dichotomines / terihanines / cassiarine C / kalasinamide / geovanine / scorpionone / asiaticumine A / マイクロ波 / アザ電子環状反応 / (S)-(-)-dichotomine / dichotomide I / (+)-dichotomide II / kalasinamid / scorpinone / dichotomine A / dichotomide II / cassiarin C / (S)-(-)-dichotomine A |
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| Outline of Final Research Achievements |
Total syntheses of condensed heterocyclic natural products dichotomide I, marinacarbolines A~D, (S)-(-)-Dichotomine A, (R)-(+)-dichotomine A, (+)-dichotomide II, (-)-dichotomide II, terihanine, isoterihanine, (±)-cassiarine C, kalasinamide, geovanine, marcanine, scorpinone were completed by the construction of appropriate fused pyridine structures based on the microwave-assisted azaelectrocyclic reaction. The stereochemistry of (+)-dichotomide II was determined as R-configuration. An asymmetric synthesis of asiaticumine A was under investigation.
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