Detailed study on the immunoactive sequence of glycosaminoglycans.
| Project/Area Number |
24590046
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
TOIDA Toshihiko 千葉大学, 薬学研究科(研究院), 教授 (60163945)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Keywords | グリコサミノグリカン / 免疫賦活活性 / 糖鎖配列 / コンドロイチン硫酸 / 活性中心 / 経口吸収 / 質量分析 / 二酸化チタン / 光分解 / 低分子化 |
|---|
| Outline of Final Research Achievements |
We have isolated and characterized new chondroitin sulfate sampls from several shark cartilage and examined their binding property to some important biological substances such as midkine and preiotrophin. Furthermore, we have looked at in vivo effects of new chondroitin sulfates on elongation of neurites of mouse embryonic nuroblasts and have found that new chondroitin sulfate samples showed strong effects on neurite elongation compared to usual chondroitin sulfate isolated from whale/bovine cartilage.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Distinguishing mild cognitive impairment from Alzheimer's disease with acrolein metabolites and creatinine in urine.2015
Author(s)
Yoshida M, Higashi K, Kuni K, Mizoi M, Saiki R, Nakamura M, Waragai M, Uemura K, Toida T, Kashiwagi K, Igarashi K.
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Journal Title
Clin Chim Acta
Volume: 441
Pages: 115-121
Related Report
Peer Reviewed / Open Access
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