Development of derivatization reagents for mass spectrometry and sensitive analysis of the biomolecules
Project/Area Number |
24590047
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Physical pharmacy
|
Research Institution | The University of Tokyo |
Principal Investigator |
Santa Tomofumi 東京大学, 薬学研究科(研究院), 教授 (30187306)
|
Project Period (FY) |
2012-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 標識試薬 / 質量分析 / クロマトグラフィー / 生体分子 / 新生児マススクリーニング / LC/MS/MS / ナノ粒子 |
Outline of Final Research Achievements |
Liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) is widely used method. In this research, the labeling reagents were synthesized to enhance the sensitivity and selectivity in LC/MS/MS. The reagents for LC/MS/MS enabled sensitive analysis of the biomolecules such as diseases markers. These methods were useful for the screening of the inherited metabolic disorders.
|
Report
(5 results)
Research Products
(8 results)