Redox regulation of metabolic processes and oxidative stress in high-fat diet-induced obese mice
| Project/Area Number |
24590052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
YAMATO Mayumi 九州大学, 学内共同利用施設等, 准教授 (30380695)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMADA Kenichi 九州大学, 薬学研究院 (60346806)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 酸化ストレス / 肥満 / エネルギー代謝 / レドックス制御 |
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| Outline of Final Research Achievements |
Obesity is a condition of well-developed adipose tissue, which causes functional abnormalities of energy metabolism. Continuous conversion of energy is controlled by reduction-oxidation (redox) processes. Oxidized and reduced nicotinamide adenine dinucleotide (NAD+ and NADH) are an important redox couple for energy metabolism. The ratio of NAD+/NADH has been implicated in oxidative stress. 4-Hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (tempol) is a redox-cycling nitroxyl radical that promotes the scavenging of several reactive oxygen species, and is reduced simultaneously to the hydroxylamine by NADH. Tempol is also involved in NAD+ production in the ascorbic acid-glutathione redox cycle. We utilized the chemical properties of tempol to clarify the effect of antioxidants and NAD+/NADH modulators on metabolic imbalance in obese mice. Increases in the NAD+/NADH ratio by tempol ameliorated metabolic imbalance in combination with dietary improvement.
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Report
(4 results)
Research Products
(8 results)
