| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Obesity is a condition of well-developed adipose tissue, which causes functional abnormalities of energy metabolism. Continuous conversion of energy is controlled by reduction-oxidation (redox) processes. Oxidized and reduced nicotinamide adenine dinucleotide (NAD+ and NADH) are an important redox couple for energy metabolism. The ratio of NAD+/NADH has been implicated in oxidative stress. 4-Hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (tempol) is a redox-cycling nitroxyl radical that promotes the scavenging of several reactive oxygen species, and is reduced simultaneously to the hydroxylamine by NADH. Tempol is also involved in NAD+ production in the ascorbic acid-glutathione redox cycle. We utilized the chemical properties of tempol to clarify the effect of antioxidants and NAD+/NADH modulators on metabolic imbalance in obese mice. Increases in the NAD+/NADH ratio by tempol ameliorated metabolic imbalance in combination with dietary improvement.
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