Development of enhanced skin permeation of drug by its selective hair follicle delivery.

• Project/Area Number: 24590057
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Josai University
• Principal Investigator: HIROAKI Todo 城西大学, 薬学部, 准教授 (10383184)
• Co-Investigator(Renkei-kenkyūsha): SUGIBAYASHI Kenji 城西大学, 薬学部, 教授
• Research Collaborator: KIJIMA Shosho ; YOSHIMOTO Masato
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 経皮吸収 / 毛嚢デリバリー / 毛嚢寄与率 / 毛嚢選択デリバリー / ビエゾ感圧アプリケーター / 皮膚透過 / 促進法 / 皮内動態 / 毛嚢内動態 / 皮内動態解析

Outline of Final Research Achievements

The contribution of hair follicle route against the total its skin permeation was increased with an increase of its lipophilicity. Almost one hundred percent of the contribution of hair follicle route against the total skin permeation was observed when a low molecular of hydrophilic drug (log Ko/w<0 and less than 500 Da molecular weight) was applied topically. In addition, a steady-state hair follicle concentration was observed in a short time after topical application of lipophilic drugs (log Ko/w<0). Furthermore, combined application of a piezo applicator and constant voltage type iontophoresis could effectively deliver a small amount of drug into hair follicle and significantly improve the skin permeation. These results suggest that selective drug delivery to hair follicle with a piezo applicator would be useful to improve drug permeation through skin.

Research Products

• [Journal Article] Analysis of the pretreatment effect of ethanol on the stratum corneum- and hair follicular penetration of drugs using the hair follicle-plugging method (2014)
  • Author(s): Daisuke Horita, Hiroaki Todo and Kenji Sugibayashi
  • Journal Title: Chem. Pharm. Bull. Volume: 62 Pages: 578-585
  • NAID: 130004137267
  • Peer Reviewed / Open Access
• [Journal Article] Potential of imaging analysis in establishing skin concentration-distance profiles for topically applied FITC-dextran 4 kDa (2014)
  • Author(s): Shosho Kijima, Ryosuke Masaki, Wesam R. Kadhum, Hiroaki Todo, Tomomi Hatanaka, Kenji Sugibayashi
  • Journal Title: ADMET & DMPK Volume: 2 Pages: 221-234
  • Peer Reviewed / Open Access
• [Presentation] Usefulness of constant current-assisted nano-dose delivery to minimal target site after drug application with a new nano-dose applicator (2014)
  • Author(s): Shosho Kijima, Wesam R. Kadhum, Hiroaki Todo, Kenji Sugibayashi
  • Organizer: 3rd International conference nutraceutical and cosmetic sciences
  • Place of Presentation: Shinjuku
  • Year and Date: 2014-11-11 – 2014-11-12
• [Presentation] 薬物の毛嚢移行性に関する基礎研究 (2014)
  • Author(s): 安田 勇太朗、Mohm Fadli Mohm Asmani、矢野 翔大、Wesam R. Kadhum、藤堂 浩明、Eddy Yusuf、杉林 堅次
  • Organizer: 第30回日本DDS学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-30 – 2014-07-31
• [Presentation] 画像解析による微少量薬物投与後の微小組織内分布に関する研究 (2014)
  • Author(s): 喜島 小翔、Wesam R. Kadhum、藤堂 浩明、杉林 堅次
  • Organizer: 日本薬剤学会 第29年会
  • Place of Presentation: 大宮
  • Year and Date: 2014-05-20 – 2014-05-22
• [Presentation] 毛嚢プラッギング法を用いた薬物の皮膚透過に及ぼす毛嚢ルート寄与率の算出 (2014)
  • Author(s): 吉元 将人、堀田 大介、Mohm Fadli Mohm Asmani、藤堂 浩明、杉林 堅次
  • Organizer: 日本薬学会 第134年会
  • Place of Presentation: 熊本
• [Presentation] 磁性粒子と磁場併用による水溶性高分子の毛嚢選択送達性の修飾 (2013)
  • Author(s): 小宅 哲史、大竹 厚史、喜島 小翔、堀田 大介、藤堂 浩明、杉林 堅次
  • Organizer: 日本薬剤学会 第28回会
  • Place of Presentation: 名古屋
• [Presentation] 毛嚢プラッギング法を用いた薬物の皮膚透過に及ぼす毛嚢ルートの寄与評価 (2013)
  • Author(s): 吉元 将人、堀田 大介、藤堂 浩明、杉林 堅次
  • Organizer: 第29回日本DDS学会学術集会
  • Place of Presentation: 京都