Profiling analysis of post-translational oxidative modification of amyloid-beta in brain
| Project/Area Number |
24590061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
INOUE Koichi 静岡県立大学, 薬学部, 講師 (30339519)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 質量分析法 / アルツハイマー / 認知症 / アミロイドタンパク質 / アルツハイマー病 / 翻訳後修飾 / アミロイドβ / 液体クロマトグラフィー質量分析 / 酸化ストレス |
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| Outline of Final Research Achievements |
The spontaneous accumulation of chemical modifications within a bio-molecule can be regarded as an aging process. Since the post-translational modification of proteins in the brain may affect the folding and turnover regarding neurons, they reduce the activate protein functionality over time and may be linked to the neurodegenerative pathology. Alzheimer’s disease is diagnosed by the progressive decline in cognitive functions, and has substantially increased among people aged 65 years or more, with a progressive decline in memory, thinking, affections, language, and learning capacity from the normal age-related decline in cognitive functions.This study is a first discussion of how research into one hypothesis, the so-called racemization/isomerization of aspartyl residues in amyloid peptides, is enabling researchers to identify ways to develop early and effective treatments for Alzheimer’s disease.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Simultaneous determination of post-translational racemization and isomerization of N-terminal amyloid-β in Alzheimer's brain tissues by covalent chiral derivatized ultraperformance liquid chromatography tandem mass spectrometry.2014
Author(s)
Inoue, K., Hosaka, D., Mochizuki, N., Akatsu, H., Tsutsumiuchi, K., Hashizume, Y., Matsukawa, N., Yamamoto, T., Toyo'oka, T.
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Journal Title
Analytical Chemistry
Volume: 86
Pages: 797-804
Related Report
Peer Reviewed
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[Journal Article] Metabolic profiling of Alzheimer’s disease brains.2013
Author(s)
Inoue, K., Tsutsui, H., Akatsu, H., Hashizume, Y., Matsukawa, N., Yamamoto, T., Toyo'oka, T.
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Journal Title
Scientific Reports
Volume: 3
Pages: 2364-2364
Related Report
Peer Reviewed
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