| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The spontaneous accumulation of chemical modifications within a bio-molecule can be regarded as an aging process. Since the post-translational modification of proteins in the brain may affect the folding and turnover regarding neurons, they reduce the activate protein functionality over time and may be linked to the neurodegenerative pathology. Alzheimer’s disease is diagnosed by the progressive decline in cognitive functions, and has substantially increased among people aged 65 years or more, with a progressive decline in memory, thinking, affections, language, and learning capacity from the normal age-related decline in cognitive functions.This study is a first discussion of how research into one hypothesis, the so-called racemization/isomerization of aspartyl residues in amyloid peptides, is enabling researchers to identify ways to develop early and effective treatments for Alzheimer’s disease.
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