| Project/Area Number |
24590068
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
KIRINO YUTAKA 徳島文理大学, 薬学部, 教授 (10012668)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIMOTO Yasushi 徳島文理大学, 香川薬学部, 准教授 (90441592)
KUBOTA Takashi 徳島文理大学, 香川薬学部, 助教 (90412402)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Shigeyuki 浜松ホトニクス(株), 中央研究所, 研究員 (10382201)
SUZUKI Kazutaka 浜松ホトニクス(株), 中央研究所, 研究員 (20394190)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 生物物理化学 / 瞬目反射条件付け / 学習・記憶 / サル / PET |
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| Outline of Final Research Achievements |
We developed a system which enables us to measure eyeblink conditioning in a monkey species (Macaca mulatta) with a brain size suitable for PET imaging. Eyeblinking was monitored simultaneously by orbicularis oculi electromyographic measurements and a high-speed camera. This system based on the two different principles yielded an interesting finding that the probability of observing a conditioned response in a given trial was not influenced by whether the monkeys closed their eyelids just before conditioned stimulus, suggesting that this memory could be expressed independently of wakefulness.
We tried to gain PET imaging using a selective agonist cannabinoid-1 receptor tracer [11C]CB-119. However, the attempt was not completed due to the limited availability of expensive animals and PET ligands. Nevertheless, this study presents a novel system for cognitive assessment in monkeys that will be useful for elucidating the neural mechanisms of implicit learning in nonhuman primates.
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