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Fatty acid elongase ELOVL1: function and diseases

Research Project

Project/Area Number 24590073
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionHokkaido University

Principal Investigator

SASSA Takayuki  北海道大学, 薬学研究科(研究院), 講師 (20342793)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords極長鎖脂肪酸 / スフィンゴ脂質 / 皮膚バリア / セラミド / 脂質
Outline of Final Research Achievements

To elucidate the function of saturated and monounsaturated very long-chain fatty acids, we made mice lacking Elovl1, the gene responsible for very long-chain-fatty acid production. Elovl1 knockout mice exhibited impaired epidermal permeability barrier and died neonatally. In the epidermis of Elovl1 knockout mice, the level of acylceramides, the lipids important for epidermal permeability barrier, was severely reduced, demonstrating that Elovl1 is one of the enzyme essential for the synthesis of acylceramides.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (25 results)

All 2015 2014 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (17 results) (of which Invited: 1 results) Remarks (3 results)

  • [Journal Article] Metabolism of very long-chain fatty acids : genes and pathophysiology2014

    • Author(s)
      Sassa T, Kihara A
    • Journal Title

      Biomol. Ther

      Volume: 22 Issue: 2 Pages: 83-92

    • DOI

      10.4062/biomolther.2014.017

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid2014

    • Author(s)
      Sassa T, Wakashima T, Ohno Y, Kihara A
    • Journal Title

      Journal of lipid research

      Volume: 55 Issue: 3 Pages: 524-530

    • DOI

      10.1194/jlr.m044586

    • NAID

      120005457018

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impaired epidermal permeability barrier in mice lacking the Elovl1 gene responsible for very long-chain fatty acid production.2013

    • Author(s)
      Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, Hirayama T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A.
    • Journal Title

      Mol Cell Biol

      Volume: 33 Issue: 14 Pages: 2787-2796

    • DOI

      10.1128/mcb.00192-13

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cooperative synthesis of ultra long-chain fatty acid and ceramide during keratinocyte differentiation.2013

    • Author(s)
      Mizutani Y, Sun, H Ohno Y, Sassa T, Wakashima T, Obara M, Yuyama K, Kihara A and Igarashi Y.
    • Journal Title

      PLoS One

      Volume: 8

    • NAID

      120005322424

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mutation for nonsyndromic mental retardation in the trans-2-enoyl-CoA reductase TER gene involved in fatty acid elongation impairs the enzyme activity and stability, leading to change in sphingolipid profile2013

    • Author(s)
      Abe K, Ohno Y, Sassa T, Taguchi R, Çali şkan, M, Ober C, Kihara A
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Issue: 51 Pages: 36741-36749

    • DOI

      10.1074/jbc.m113.493221

    • NAID

      120005385316

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Aldh3a2 knockout mice as a potential model for Sjogren-Larsson syndrome.2015

    • Author(s)
      Sassa T, Kanetake T, Naganuma T, Takagi S, Kitamura T and Kihara A
    • Organizer
      6th International Conference on Phospholipase A2 and Lipid Mediators (PLM2015)
    • Place of Presentation
      Keio Plaza Hotel, Shinjuku, Tokyo
    • Year and Date
      2015-02-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] C24極長鎖脂肪酸の生理機能と病態への関与2014

    • Author(s)
      佐々貴之
    • Organizer
      第7回セラミド研究会学術集会
    • Place of Presentation
      東京 ユビキタス協創広場 CANVAS,東京
    • Year and Date
      2014-10-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] シェーグレン・ラルソン症候群原因遺伝子Aldh3a2 KOマウスを用いた脳における生化学的解析2014

    • Author(s)
      金武司, 佐々貴之, 高木秀侑, 永沼達郎, 木原章雄
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都国際会議場,京都
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] シェーグレン・ラルソン症候群原因遺伝子ALDH3A2の表皮における機能解析2014

    • Author(s)
      高木秀侑, 永沼達郎, 金武司, 北村拓也, 佐々貴之, 木原章雄
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都国際会議場,京都
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] シェーグレン・ラルソン症候群原因遺伝子Aldh3a2の欠損はマウスケラチノサイトにおいて細胞増殖の亢進とアシルセラミド量の低下を引き起こす2014

    • Author(s)
      永沼達郎, 高木秀侑, 金武司, 北村拓也, 佐々貴之, 木原章雄
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都国際会議場,京都
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] シェーグレン・ラルソン症候群における皮膚魚鱗癬発症メカニズムの解析2014

    • Author(s)
      永沼達郎, 高木秀侑, 金武司, 北村拓也, 佐々貴之, 木原章雄
    • Organizer
      日本生化学会北海道支部第51回支部例会
    • Place of Presentation
      北海道大学百年記念会館,札幌
    • Year and Date
      2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] シェーグレン・ラルソン症候群原因遺伝子Aldh3a2ノックアウトマウスを用いた神経症状発症の分子機構の解析2014

    • Author(s)
      佐々貴之, 金武司, 高木秀侑, 永沼達郎, 木原章雄
    • Organizer
      第56回日本脂質生化学会
    • Place of Presentation
      近畿大学,大阪
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] シェーグレン・ラルソン症候群原因遺伝子Aldh3a2の中枢神経系における機能解析2014

    • Author(s)
      金武司, 佐々貴之, 高木秀侑, 永沼達郎, 木原章雄
    • Organizer
      日本薬学会北海道支部141回例会
    • Place of Presentation
      札幌コンベンションセンター,札幌
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mice lacking the Elovl1 gene responsible for very long-chain fatty acid production exhibit neonatal lethality due to impaired epidermal permeability barrier.2013

    • Author(s)
      Sassa T, Ohno Y, Suzuki S, Nomura T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A.
    • Organizer
      FASEB Summer Research conferences (Lysophospholipid and Other Related Mediators - From Bench to Clinic)
    • Place of Presentation
      Hilton Niseko Village, Niseko, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Loss of ELOVL1 enzyme causes lethal skin barrier disruption in mice.2013

    • Author(s)
      Suzuki S, Nomura T, Sassa T, Ohno Y, Nakamura H, Akiyama M, Kihara A and Shimizu H.
    • Organizer
      40th Annual Meeting of Society for Cutaneous Ultrastructure Research
    • Place of Presentation
      Castellani Parkhotel, Sarzburg, Austria
    • Related Report
      2013 Research-status Report
  • [Presentation] Loss of ELOVL1 enzyme depletes very long-chain fatty acids and causes lethal skin barrier disruption in mice.2013

    • Author(s)
      Suzuki S, Nomura T, Sassa T, Ohno Y, Akiyama M, Kihara A and Shimizu H.
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      The Edinburgh International Conference Centre, Edinburgh, UK
    • Related Report
      2013 Research-status Report
  • [Presentation] Functional characterization of very long-chain sphingolipids produced by ELOVL12012

    • Author(s)
      Takayuki Sassa and Akio Kihara
    • Organizer
      Gordon Research Conference, Glycolipid and Sphingolipid Biology
    • Place of Presentation
      Renaissance Tuscany Il Ciocco Resort (Italy)
    • Related Report
      2012 Research-status Report
  • [Presentation] Fatty acid elongase Elovl1 is essential for the synthesis of ≥C26 ceramides and epidermal permeability barrier formation.

    • Author(s)
      Sassa T, Ohno Y, Suzuki S, Nomura T, Akiyama M, Taguchi R, Shimizu H, Itohara S and Kihara A.
    • Organizer
      Gordon Research Conference (Glycolipid & Sphingolipid Biology)
    • Place of Presentation
      Four Points Sheraton, Ventura, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 極長鎖脂肪酸伸長酵素Elovl1は表皮において層特異的な制御を受け皮膚バリアに必須の役割を果たす.

    • Author(s)
      佐々貴之, 大野祐介, 鈴木翔多朗, 乃村俊史, 秋山真志, 田口良, 清水宏, 糸原重美, 木原章雄.
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜,横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] ELOVL1の欠損は致死的な皮膚バリア障害を引き起こす.

    • Author(s)
      鈴木翔多朗, 乃村俊史, 佐々貴之, 大野祐介, 中村秀樹, 秋山真志, 木原章雄, 清水宏.
    • Organizer
      第40回皮膚かたち研究学会学術大会
    • Place of Presentation
      石垣記念ホール,東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 常染色体劣性遺伝精神遅滞に見られるTER P182L変異体の生化学的解析.

    • Author(s)
      安部健介, 大野祐介, 佐々貴之, 木原章雄.
    • Organizer
      第55回日本脂質生化学会
    • Place of Presentation
      松島大観荘,仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] 家族性精神遅滞に見られるTER P182L変異体の生化学的解析.

    • Author(s)
      安部健介, 大野祐介, 佐々貴之, 木原章雄.
    • Organizer
      日本薬学会北海道支部140回例会
    • Place of Presentation
      札幌コンベンションセンター,札幌
    • Related Report
      2013 Research-status Report
  • [Remarks] 北海道大学 大学院薬学研究院 生化学研究室

    • URL

      http://www.pharm.hokudai.ac.jp/seika/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 北海道大学 薬学研究院 生化学研究室

    • URL

      http://www.pharm.hokudai.ac.jp/seika/index.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 北海道大学 大学院薬学研究院 創薬科学部門 生体機能科学分野 生化学研究室

    • URL

      http://www.pharm.hokudai.ac.jp/seika/index.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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