Fatty acid elongase ELOVL1: function and diseases
| Project/Area Number |
24590073
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
SASSA Takayuki 北海道大学, 薬学研究科(研究院), 講師 (20342793)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 極長鎖脂肪酸 / スフィンゴ脂質 / 皮膚バリア / セラミド / 脂質 |
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| Outline of Final Research Achievements |
To elucidate the function of saturated and monounsaturated very long-chain fatty acids, we made mice lacking Elovl1, the gene responsible for very long-chain-fatty acid production. Elovl1 knockout mice exhibited impaired epidermal permeability barrier and died neonatally. In the epidermis of Elovl1 knockout mice, the level of acylceramides, the lipids important for epidermal permeability barrier, was severely reduced, demonstrating that Elovl1 is one of the enzyme essential for the synthesis of acylceramides.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Impaired epidermal permeability barrier in mice lacking the Elovl1 gene responsible for very long-chain fatty acid production.2013
Author(s)
Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, Hirayama T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A.
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Journal Title
Mol Cell Biol
Volume: 33
Issue: 14
Pages: 2787-2796
DOI
Related Report
Peer Reviewed
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[Presentation] Mice lacking the Elovl1 gene responsible for very long-chain fatty acid production exhibit neonatal lethality due to impaired epidermal permeability barrier.2013
Author(s)
Sassa T, Ohno Y, Suzuki S, Nomura T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A.
Organizer
FASEB Summer Research conferences (Lysophospholipid and Other Related Mediators - From Bench to Clinic)
Place of Presentation
Hilton Niseko Village, Niseko, Japan
Related Report
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