Analysis of the mechanism of the regulation of proteasome by novel modifier PI31
| Project/Area Number |
24590075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HAMAZAKI Jun 東京大学, 薬学研究科(研究院), 助教 (80533588)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | プロテアソーム / タンパク質分解 / ユビキチン |
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| Outline of Final Research Achievements |
Proteasome is a essential protease complex that is conserved in eukaryotes. Recently, we identified PI31 as a novel proteasome function modifier. We observed PI31 knockdown fly shows signify defect in development and cell homeostasis. We conducted the biochemical study about PI31 and generated the PI31 conditional knockout mice.
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Report
(4 results)
Research Products
(23 results)
