Analyses of glycan function characteristic for human B cells
| Project/Area Number |
24590078
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKEMATSU Hiromu 京都大学, 医学(系)研究科(研究院), 准教授 (80324680)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 糖鎖抗原 / 免疫応答 / シグナル伝達経路 / 胚中心 / 抗体 / 糖脂質 / B細胞抗原受容体シグナル伝達 / 免疫 / Bリンパ球 / 活性化 / 国際情報交換 |
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| Outline of Final Research Achievements |
Germinal center reaction is essential for acquired immunity. In germinal center, B cells undergo important immunoglobulin gene modification such as class switching and affinity maturation, which enable optimal immunity. Mouse has served as a nice model to study immunity. However, considerable difference was found between these two species. Cell surface glycans are one of those differences. Here we focused onto the glycans whose expression is regulated in germinal center B cells. We created model B cells with various change only on glycans. This set of cells are optimal for BCR signaling studied because germinal center B cells differ quite a lot from mature B cells, other than cell surface glycans. Thus comparison of normal mature B and germinal center B cells make it difficult to understand. We found that each marker glycans account for signaling events downstream BCR to achieve optimal B cell activation.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Functional evaluation of activation-dependent alterations in the sialoglycan composition of T cells.2014
Author(s)
Naito-Matsui Y, Takada S, Kano Y, Iyoda T, Sugai M, Shimizu A, Inaba K, Nitschke L, Tsubata T, Oka S, Kozutsumi Y, and Takematsu H.
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Journal Title
J. Biol. Chem.
Volume: 289
Issue: 3
Pages: 1564-1579
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Structural and biochemical characterization of O-mannose-linked HNK-1 glycan expressed on phosphacan in developing mouse brains.2014
Author(s)
Morise J, Kizuka Y, Yabuno K, Tonoyama Y, Hashii N, Kawasaki N, Manya H, Miyagoe-Suzuki Y, Takeda S, Endo T, Maeda N, Takematsu H, and Oka S.
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Journal Title
Glycobiology
Volume: 24
Issue: 3
Pages: 314-324
DOI
Related Report
Peer Reviewed / Open Access
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