| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
Germinal center reaction is essential for acquired immunity. In germinal center, B cells undergo important immunoglobulin gene modification such as class switching and affinity maturation, which enable optimal immunity. Mouse has served as a nice model to study immunity. However, considerable difference was found between these two species. Cell surface glycans are one of those differences. Here we focused onto the glycans whose expression is regulated in germinal center B cells. We created model B cells with various change only on glycans. This set of cells are optimal for BCR signaling studied because germinal center B cells differ quite a lot from mature B cells, other than cell surface glycans. Thus comparison of normal mature B and germinal center B cells make it difficult to understand. We found that each marker glycans account for signaling events downstream BCR to achieve optimal B cell activation.
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