| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Cell-surface F1F0-ATP synthase plays a role on intracellular triacylglycerol (TG) accumulation in adipocytes. Here we show that cell-surface F1F0-ATP synthase on adipocytes is functional in extracellular ATP production and that the extracellular ATP produced contributes, at least in part, to the cell-surface F1F0-ATP synthase-mediated intracellular triacylglycerol (TG) accumulation in adipocytes through P2Y1 receptor. We synthesized water-soluble resveratrol and piceatannol which are F1F0-ATP synthase inhibitors) and found that these compounds significantly lowered abdominal visceral adipose tissue in diet-induced obese mice.
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