| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Many plasma membrane-resident proteins collaborate with other molecules by molecular interactions in a variety of biological events. Herein, we have identified the molecular complexes (heterodimer complexes) expressed specifically in mouse primary lung cancer cells derived from EML4-ALK transgenic mouse as a mouse model of lung cancer. We also focused on the molecular complexes consist of overexpressed-cell surface molecules to assess whether these complexes give rise to cancer progression.
We found the expression of some cell surface molecules was up-regulated, and these overexpressed molecules formed the complexes with several cell surface molecules (alpha and beta integrin etc.). To assess the influence of the complexes, we have developed the cells expressed these candidate overexpressed-cell surface molecular complexes.
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