| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Environmental and metabolic changes induce various stress responses in cells and tissues to maintain the homeostasis, however uncontrollable continuous and strong stress will lead the homeostatic disorders and consequently to various diseases. We investigated that contribution of TRB1 and TRB3, which are induced by various stresses, to a variety of stress responses and onset of various diseases. Antigen-stimulation induces the TRB1 expression and it up-regulated the immune responses. One of the antiproliferative cytokines , TGF-beta also induced TRB1, which inhibited its signaling. It was known that both TRB1 and TRB3 are over expressed in a number of cancers. We clarified that TRB1 inhibited the function of typical tumor-suppressor gene, p53, and that TRB3 disturbed the cell cycle checkpoint. It was indicated that the two molecules advantageously act for the progression of cancer cells.
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