Molecular bases of cellular stress and disease development regulated by by stress inducible molecules, TRB1 and TRB3
Project/Area Number |
24590085
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | Nagoya City University |
Principal Investigator |
HAYASHI Hidetoshi 名古屋市立大学, 薬学研究科(研究院), 教授 (80198853)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | TRB1 / TRB3 / p53 / checkpoint / HDAC1 / stress / cell cycle / 小胞体ストレス / DNA損傷 / タンパク質分解 / 転写制御 / がん化 / pseudokinase / DNA 損傷 |
Outline of Final Research Achievements |
Environmental and metabolic changes induce various stress responses in cells and tissues to maintain the homeostasis, however uncontrollable continuous and strong stress will lead the homeostatic disorders and consequently to various diseases. We investigated that contribution of TRB1 and TRB3, which are induced by various stresses, to a variety of stress responses and onset of various diseases. Antigen-stimulation induces the TRB1 expression and it up-regulated the immune responses. One of the antiproliferative cytokines , TGF-beta also induced TRB1, which inhibited its signaling. It was known that both TRB1 and TRB3 are over expressed in a number of cancers. We clarified that TRB1 inhibited the function of typical tumor-suppressor gene, p53, and that TRB3 disturbed the cell cycle checkpoint. It was indicated that the two molecules advantageously act for the progression of cancer cells.
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Report
(5 results)
Research Products
(104 results)
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[Presentation] TGFβによるPPARγ発現抑制と脂肪蓄積の制御2014
Author(s)
楽 怡, 鈴木美沙紀, 井上万由美, 伊藤友香, 岡山敦子, 野口祐美子, 舛田悠介, 井上靖道, 小野嵜菊夫, 斉藤昌之, 林 秀敏
Organizer
第15回Pharmaco-Hematologyシンポジウム
Place of Presentation
名古屋市立大学(愛知県・名古屋)
Year and Date
2014-05-23
Related Report
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[Presentation] 天然由来AhRアゴニストの探索研究2012
Author(s)
田邊宏樹, 鈴木彩世, 中島健一, 林 秀敏, 井上 誠
Organizer
日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2012
Place of Presentation
長良川国際会議場(岐阜県・岐阜)
Year and Date
2012-11-18
Related Report
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