| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The actions of tetrahydrocannabinol are known to be mediated by two G-protein-coupled receptors CB1 and CB2. Recently, another receptor GPR55 has been proposed as a novel type of cannabinoid receptor. We identified lysophosphatidylinositol (LPI) as an agonist for GPR55, and found that the intracellular phospholipase A1 (DDHD1) was involved in the formation of 2-arachidonoyl LPI. We also found that 1-stearoyl LPI was formed by the reverse reaction of lysophosphatidylinositol acyltranferase (LPIAT/MBOAT7).
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