Research for the novel metabolic routes of endogenous marijuana-like substance, lysophosphatidylinosiol.
Project/Area Number |
24590095
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | Teikyo University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
SASAKI Yoko (NEMOTO Yoko) 帝京大学, 薬学部, 講師 (90324110)
HAYASHI Yasuhiro 帝京大学, 薬学部, 助教 (70582857)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | リゾリン脂質 / ホスホリパーゼA / ホスファチジルイノシトール / リゾホスファチジルイノシトール / ホスファチジン酸 / 遺伝性痙性対麻痺 / カンナビノイド / GPR55 / ホスホリパーゼA1 / リゾホスファチジン酸 / マリファナ / リゾリン脂質メディエーター / マリファナ受容体 / アシルトランスフェラーゼ |
Outline of Final Research Achievements |
The actions of tetrahydrocannabinol are known to be mediated by two G-protein-coupled receptors CB1 and CB2. Recently, another receptor GPR55 has been proposed as a novel type of cannabinoid receptor. We identified lysophosphatidylinositol (LPI) as an agonist for GPR55, and found that the intracellular phospholipase A1 (DDHD1) was involved in the formation of 2-arachidonoyl LPI. We also found that 1-stearoyl LPI was formed by the reverse reaction of lysophosphatidylinositol acyltranferase (LPIAT/MBOAT7).
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Report
(4 results)
Research Products
(50 results)
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[Presentation] Sphingomyelin synthase 2, but not sphingomyelin synthase 1, is involved in HIV-1 envelope-mediated membrane fusion.2015
Author(s)
Yasuhiro Hayashi, Yoko Nemoto-Sasaki, Naoki Matsumoto, Kiyoto Tsuchiya, Kouta Zama, Susumu Mitsutake, Takayuki Sugiura, and Atsushi Yamashita
Organizer
6th international conference on Phospholipase A2 and Lipid Mediators (PLM2015)
Place of Presentation
Tokyo, Japan
Year and Date
2015-02-10 – 2015-02-12
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[Presentation] ヒト大腸がん細胞において低酸素下で誘導されるエーテル型リン脂質の著しい増加とそのメカニズム2012
Author(s)
小泉 恵子, 清水 嘉文, 神奈木 玲児, 田中 広治, 山下 純, 田中 保, 鈴木 元, 村手 隆, 岩城 壮一郎, 藤井 聡, 徳村 彰
Organizer
第85回日本生化学会大会
Place of Presentation
福岡
Related Report
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[Presentation] ヒト大腸がん細胞でのリゾリン脂質代謝に対する低酸素の影響2012
Author(s)
清水 嘉文, 小泉 恵子, 岸野 恵理佳, 神奈木 玲児, 田中 広治, 山下 純, 田中 保, 鈴木 元, 村手 隆, 岩城 壮一郎, 藤井 聡, 徳村 彰
Organizer
第85回日本生化学会大会
Place of Presentation
福岡
Related Report
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