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Molecular basis of the avian memory formation regulated by cytoskelton binding protein

Research Project

Project/Area Number 24590096
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionTeikyo University

Principal Investigator

YAMAGUCHI Shinji  帝京大学, 薬学部, 准教授 (60398740)

Co-Investigator(Renkei-kenkyūsha) AOKI Naoya  帝京大学, 薬学部, 助教 (60525334)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords生化学 / 行動生化学 / 分子生物学 / 記憶 / 刻印付け
Outline of Final Research Achievements

Birds have a diverse behavioral repertoire and are thus ideal models for experimental analyses of neural and behavioral plasticity. The domestic chick has been intensively studied as a model for filial imprinting. To elucidate the molecular processes underlying the neural mechanism of filial imprinting in newly-hatched chicks more extensively, we previously conducted a cDNA microarray and the quantitative RT-PCR study. One of the genes was microtubule-associated protein 2 (MAP2), which is involved in cytoskeletal organization. Here, we used in vivo gene-transfer technique and showed that transfected microRNA vectors preferentially silence exogenous DNA expression in neuronal cells. Using this system, the up-regulation of MAP2 accompanying filial imprinting was suppressed in vivo, which impaired the filial imprinting in chicks. Our results suggest that the regulation of MAP2 expression is required for filial imprinting.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (22 results)

All 2015 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) Book (1 results) Remarks (5 results)

  • [Journal Article] Expression of the voltage-sensing phosphatase gene in the chick embryonic tissues and in the adult cerebellum2014

    • Author(s)
      Yamaguchi, S., Aoki, N., Kitajima, T., Okamura, Y. and Homma, K. J.
    • Journal Title

      Communicative & Integrative Biology

      Volume: 7 Issue: 5 Pages: 1-4

    • DOI

      10.4161/19420889.2014.970502

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Potential role of voltage-sensing phosphatases in regulation of cell structure through the production of PI(3,4)P<sub>2</sub>2013

    • Author(s)
      Yamaguchi S, Kurokawa T, Taira I, Aoki N, Sakata S, Okamura Y & Homma KJ
    • Journal Title

      J. Cell Physiol.

      Volume: 229 Issue: 4 Pages: 422

    • DOI

      10.1002/jcp.24463

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A primer for learning: Thyroid hormone determines the start of the sensitive period of filial imprinting of domestic chicks2013

    • Author(s)
      homma, K.J., Yamaguchi,S. Y., Aoki, N.
    • Journal Title

      Seikagaku

      Volume: 85(5) Pages: 315-327

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 鳥類刷り込みに見られるメモリープライミング2013

    • Author(s)
      本間 光一、山口 真二、青木 直哉
    • Journal Title

      分子精神医学

      Volume: 13(4) Pages: 243-250

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Thyroid hormone determines the start of the sensitive period of imprinting and primes later learning2012

    • Author(s)
      Yamaguchi, S., Aoki, N., Kitajima, T.Iikubo, E., Katagiri, S., Matsushima,T., Homma,K.J.
    • Journal Title

      Nature Communications

      Volume: 3 Issue: 1 Pages: 1081-1081

    • DOI

      10.1038/ncomms2088

    • URL

      http://dx.doi.org/10.1016/j.anbehav.2012.07.026

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 3′ Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P <sub>2</sub>] by voltage-sensing phosphatase (VSP)2012

    • Author(s)
      Kurokawa T, Takasuga S, Sakata S, Yamaguchi S, Horie S, Homma KJ, Sasaki T & Okamura Y
    • Journal Title

      VSP. Proc. Natl. Acad. Sci. U.S.A.

      Volume: 109 Issue: 25 Pages: 10089

    • DOI

      10.1073/pnas.1203799109

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 鳥類刻印付けにおけて大脳背側部IMHAは獲得・想起に必要である2015

    • Author(s)
      青木直哉、山口真二、北島孝明、本間光一
    • Organizer
      第67回日本動物学会関東支部大会
    • Place of Presentation
      早稲田大学先端生命医科学センター
    • Year and Date
      2015-03-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 甲状腺ホルモンは、刷り込み学習の感受性期の開始を決定し、その後の学習のプライマーとして働く2014

    • Author(s)
      山口真二、青木直哉、松島俊也、本間光一
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 鳥類刻印付けの成立に大脳後背側部IMHAは必須である2014

    • Author(s)
      青木直哉、北島孝明、松島俊也、本間光一
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hormonal regulation of the sensitive period for fillial imprinting in domestic chicks.2014

    • Author(s)
      山口真二、青木直哉、本間光一
    • Organizer
      2014 International Congress of Neuroethology,Hokkaido Neuroethology workshops
    • Place of Presentation
      北海道大学理学部生命科学科
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neural circuits of the sensitive period triggered by thyroid hormones in filial imprinting.2014

    • Author(s)
      青木直哉、山口真二、本間光一
    • Organizer
      2014 International Congress of Neuroethology,Hokkaido Neuroethology workshops
    • Place of Presentation
      北海道大学理学部生命科学科
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Imprinting behavior in birds as a model of learning potency and the sensitive period2014

    • Author(s)
      Yamaguchi, S
    • Organizer
      Gordon Research Conference, Genes & Behavior
    • Place of Presentation
      Hotel Galvez in Galveston, TX, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 鳥類刻印付け感受性期の開始を決定するメモリープライミング2013

    • Author(s)
      山口真二、青木直哉、北島孝明、松島俊也、本間光一
    • Organizer
      Neuro2013(第36回日本神経科学大会)
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Research-status Report
  • [Presentation] Thyroid hormone determines the start of the sensitive period of visual imprinting

    • Author(s)
      S. YAMAGUCHI, N. AOKI, T. KITAJIMA, T. MATSUSHIMA, K. J. HOMMA
    • Organizer
      Society for Neuroscience 2012
    • Place of Presentation
      New Orleans
    • Related Report
      2012 Research-status Report
  • [Presentation] Rapid inflow of thyroid hormone induced by visual imprinting primes later learning.

    • Author(s)
      N. AOKI, S. YAMAGUCHI, T. KITAJIMA, T. MATSUSHIMA, K. J. HOMMA
    • Organizer
      Society for Neuroscience 2012
    • Place of Presentation
      New Orleans
    • Related Report
      2012 Research-status Report
  • [Presentation] 甲状腺ホルモンは鳥類親子刷り込みの感受性期の開始を決定する

    • Author(s)
      本間 光一、山口真二、青木直哉、松島俊也
    • Organizer
      日本動物学会 第83回大会 2012大阪
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Book] Insect papain homologues (In Handbook of Proteolytic Enzyme, 3rd Edition ( A. J. Barrett, N. D. Rawlings, and J. D. Woessner, eds) )2012

    • Author(s)
      Homma, K. J. , Yamaguchi, S. and Aoki, N.
    • Total Pages
      6
    • Publisher
      Academic Press
    • Related Report
      2012 Research-status Report
  • [Remarks] 帝京大学薬学部ホームページ

    • URL

      http://www.pharm.teikyo-u.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 帝京大学教員情報

    • URL

      https://www.e-campus.gr.jp/staffinfo/public/staff/detail/1303/16

    • Related Report
      2014 Annual Research Report
  • [Remarks] 帝京大学薬学部ホームページ

    • URL

      http://www.pharm.teikyo-u.ac.jp/

    • Related Report
      2013 Research-status Report
  • [Remarks] 帝京大学教員情報

    • URL

      https://www.e-campus.gr.jp/staffinfo/public/staff/detail/1303/16

    • Related Report
      2013 Research-status Report
  • [Remarks] 帝京大学ホームページ

    • URL

      http://www.teikyo-u.ac.jp/

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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