The degradation machinery of cellular and viral proteins
Project/Area Number |
24590103
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
|
Research Institution | Kyoto Pharmaceutical University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ウイルス / ヘルペスウイルス / リンパ腫 / プロテアーゼ / シグナル伝達 / 抗腫瘍薬 / ウィルス / がん / 抗ウイルス薬 / ユビキチン / ミトコンドリア / p32 / 発がん / 翻訳後修飾 / カポジ肉腫 |
Outline of Final Research Achievements |
Kaposi’s sarcoma-associated herpesvirus (KSHV; also known as HHV-8) is a rhadinovirus of the gamma-herpesvirus subfamily and the eighth human herpesvirus to be discovered. KSHV is the causative agent of Kaposi’s sarcoma and acquired immunodeficiency syndrome (AIDS)-related lymphoproliferative disorders, such as plasmablastic variant multicentric Castleman’s disease and primary effusion lymphoma (PEL). In this study, we demonstrated that KSHV-encoded the latency associated nuclear antigen (LANA) is stabilized by de-ubiquitinating enzyme (HSUSP), and enhances the replication and the maintenance of viral DNA. Forthermore, we found that the pyrrolidinium fullerene (C60) and an allyl sulfide have the antitumor activity against PEL cells, suggesting that fullerene and allyl sulfide may represent a novel therapy for the treatment of PEL.
|
Report
(4 results)
Research Products
(14 results)
-
-
[Journal Article] Notch-Nrf2 axis: Regulation of Nrf2 gene expression and cytoprotection by Notch signaling2014
Author(s)
Wakabayashi N, Skoko JJ, Chartoumpekis DV, Kimura S, Slocum SL, Noda K, Palliyaguru DL, Fujimuro M, Boley PA, Tanaka Y, Shigemura N, Biswal S, Yamamoto M, Kensler TW
-
Journal Title
Mol Cell Biol
Volume: 34
Issue: 4
Pages: 653-663
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-