| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
We investigated molecular mechanisms for cell growth regulation by Mnks-mediated translational control. We found that activation of Mnk1 resulted in rapid phosphorylation of eIF4G at Ser1105/1106. We also showed that inhibition of mTORC1 upregulated phosphorylation of eIF4E at Ser209 in human medulloblastoma cells, and that this feedback phosphorylation of eIF4E was mediated by Mnk2 but not by Mnk1. Furthermore, suppression of Mnk2 activity sensitized medulloblastoma cells to mTOR inhibitors, raising the potential for combination treatments of mTOR and Mnk inhibitors for the treatment of medulloblastoma.
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